1293281-49-8

中文名称 [2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE

英文名称 JNJ-42847922

CAS 1293281-49-8

分子式 C21H22FN7O

分子量 407.44

MOL 文件 1293281-49-8.mol

更新日期 2024/05/28 16:04:18

1293281-49-8 结构式

基本信息物理化学性质安全数据应用领域图谱信息 JNJ-42847922价格(试剂级)

基本信息

中文别名

(5-(4,6-二甲基嘧啶-2-基)六氢吡咯并[3,4-C]吡咯-2(1H)-基)(2-氟-6-(2H-1,2,3-三唑-2-基)苯基)甲酮

英文别名

JNJ-42847922
JNJ-42847922,Cid 67116280
[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone
Methanone, [5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]-
[2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE

所属类别

有机原料：杂环化合物

物理化学性质

储存条件-20°C储存

溶解度DMSO: 250 mg/mL (613.59 mM)

安全数据

危险性符号(GHS)

GHS07,GHS06

警示词危险

危险性描述H312-H319-H301-H335-H332-H315

防范说明P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P261-P271-P304+P340-P312-P264-P270-P301+P310-P321-P330-P405-P501-P280-P302+P352-P312-P322-P363-P501

应用领域

用途一

Seltorexant, also known as JNJ-42847922 and MIN-202, is a potent OX2R antagonist that has been shown to promote sleep in various species. JNJ-42847922 had an approximate 2-log selectivity ratio versus the human orexin-1 receptor. Ex vivo receptor binding studies demonstrated that JNJ-42847922 quickly occupied OX2R binding sites in the rat brain after oral administration and rapidly cleared from the brain. Seltorexant shows antidepressant and sleep-promoting effects in patients with major depressive disorder. JNJ-42847922 induces somnolence in healthy subjects without residual central effects.

图谱信息

JNJ-42847922(1293281-49-8)核磁图(¹HNMR)

JNJ-42847922价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2023/01/06	S3503	[2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE Seltorexant	1293281-49-8	25mg	4398.55元
2021/03/30	S3503	[2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE Seltorexant	1293281-49-8	5mg	1466.55元