1374601-41-8
中文名称
BRD9539
英文名称
BRD-9539
CAS
1374601-41-8
分子式
C24H21N3O3
分子量
399.44
MOL 文件
1374601-41-8.mol
更新日期
2024/05/31 11:52:16
1374601-41-8 结构式
基本信息
中文别名
G9A和PRC2抑制剂(BRD9539) 英文别名
BRD9539BRD 9539
BRD-9539
2-(BenzoylaMino)-1-(3-phenylpropyl)-1H-benziMidazole-5-carboxylic acid
1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-
所属类别
生物化工：激动剂抑制剂
BRD9539价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-15647 | BRD9539 BRD9539 | 1374601-41-8 | 5mg | 600元 |
| 2024/04/30 | HY-15647 | BRD9539 BRD9539 | 1374601-41-8 | 10mM * 1mLin DMSO | 660元 |
| 2024/04/30 | HY-15647 | BRD9539 BRD9539 | 1374601-41-8 | 10mg | 990元 |
常见问题列表
生物活性
BRD9539 是一种组蛋白甲基转移酶 G9a 抑制剂，IC50 为 6.3 μM。BRD9539 还抑制 PRC2 活性，并且对 SUV39H1，NSD2 和 DNMT1 无活性。靶点
|
G9a 6.3 μM (IC 50 ) |
PRC2
|
体外研究
BRD9539 decreases ATP levels in a dose-dependent manner in HeLa cells.
BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. However, BRD9539 has no activity in cell-based assays, presumably due to impaired cell permeability compared to that of BRD4770. In addition, the activities of 16 other chromatin-modifying enzymes and 100 kinases involved in cell-cycle regulation and cancer cell biology are tested for activity in the presence of 5 or 10 μM BRD9539; no activity is seen in any of these assays.