1415246-68-2
中文名称
MONOMETHYLAURISTATIN F HYDROCHLORIDE
英文名称
MMAF (Hydrochloride)
CAS
1415246-68-2
分子式
C39H66ClN5O8
分子量
768.423
MOL 文件
1415246-68-2.mol
更新日期
2023/03/20 15:41:25
1415246-68-2 结构式
基本信息
中文别名
细胞分裂抑制剂(MMAF HYDROCHLORIDE) 英文别名
CS-1270MMAF HCl
MMAF (Hydrochloride)
Monomethylauristatin F Hydrochloride
物理化学性质
储存条件Store at -20°C,unstable in solution, ready to use.
溶解度DMSO: 27 mg/mL (35.14 mM and warming)
MONOMETHYLAURISTATIN F HYDROCHLORIDE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-15579A | MONOMETHYLAURISTATIN F HYDROCHLORIDE MMAF hydrochloride | 1415246-68-2 | 10mg | 560元 |
| 2024/04/30 | HY-15579A | MONOMETHYLAURISTATIN F HYDROCHLORIDE MMAF hydrochloride | 1415246-68-2 | 50 mg | 1280元 |
| 2024/04/30 | HY-15579A | MONOMETHYLAURISTATIN F HYDROCHLORIDE MMAF hydrochloride | 1415246-68-2 | 100 mg | 1920元 |
常见问题列表
生物活性
MMAF (Monomethylauristatin F) hydrochloride 是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂，用作抗肿瘤药物。MMAF hydrochloride 广泛用作抗体偶联药物 (ADCs) 的细胞毒性成分，如 Vorsetuzumab mafodotin 和 SGN-CD19A。靶点
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Auristatin
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体外研究
MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC 50 s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay.
体内研究
The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF 4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF 4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively.