1513879-19-0
中文名称
KDU691
英文名称
KDU691
CAS
1513879-19-0
分子式
C22H18ClN5O2
分子量
419.86
MOL 文件
1513879-19-0.mol
更新日期
2023/03/20 15:41:25
1513879-19-0 结构式
基本信息
中文别名
化合物KDU691N-(4-氯苯基)-N-甲基-3-(4-(甲基氨基甲酰基)苯基)咪唑并[1,2-A]吡嗪-6-甲酰胺
英文别名
KDU691KDU691 >=98% (HPLC)
KDU691
KDU-691
KDU 691
1513879-19-0
Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-
所属类别
生物化工：激动剂抑制剂物理化学性质
密度1.35±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.24(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);23.82(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);23.82(Max Conc. mM)
酸度系数(pKa)14.59±0.46(Predicted)
形态结晶固体
常见问题列表
生物活性
KDU691是疟原虫PI4K特异性抑制剂，对其休眠子形式和肝内裂殖体的IC50值分别为0.18 μM和0.061 μM。靶点
| Target | Value |
|
PI4K
() |
体内研究
During the 5 days of dosing, no major weight changes are observed in the animals that receive KDU691 as prophylactic treatment (group 691-proph). From the fourth day of dosing, the animals that are treated with KDU691 show a transient yellow skin color. The KDU691 radical-cure group (group 691-RC) becomes blood-stage positive again at 31.8 days p.i. (range, 31 to 32 days). Clinical chemistry analysis of the group 691-RC monkeys reveals that bilirubin levels accumulate during the 5-day radical-cure treatment with KDU691.