15917-65-4
15917-65-4 结构式
基本信息
中文别名
N-去甲基三苯氧胺 盐酸盐N-去甲基三苯氧胺 盐酸盐/N-去甲基他莫昔芬盐酸盐
2-[4-[(1Z)-1,2-二苯基-1-丁烯基]苯氧基]-N-甲基乙胺盐酸盐
英文别名
Nsc372964N-Demethyltamoxifen Hydrochlorid
(Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine
(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N-methylethanamine Hydrochloride
2-[4-[(1Z)-1,2-Diphenyl-1-butenyl]phenoxy]-N-methylethanamine hydrochloride
常见问题列表
生物活性
N-Desmethyltamoxifen hydrochloride 是 Tamoxifen 在人体内的主要代谢产物。N-Desmethyltamoxifen，较弱的抗雌激素，是一种比 Tamoxifen 强十倍的蛋白激酶 C (PKC) 抑制剂。N-Desmethyltamoxifen hydrochloride 也是人体 AML 细胞神经酰胺代谢的有效调节因子，限制神经酰胺糖基化、水解和鞘氨醇磷酸化。体外研究
N-desmethyltamoxifen hydrochloride (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
N-desmethyltamoxifen hydrochloride (1.5-10 μM; 114 hours) inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen hydrochloride, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen.
Cell Viability Assay
| Cell Line: | MCF 7 human mammary carcinoma cells |
| Concentration: | 1.5, 2.5, 5, 7.5, 10 μM |
| Incubation Time: | 114 hours |
| Result: | Inhibits growth of MCF 7 human mammary carcinoma cells |