1700637-55-3
中文名称
CD38 inhibitor
英文名称
CD38 inhibitor 78c
CAS
1700637-55-3
分子式
C22H27N3O3S
分子量
413.53
MOL 文件
1700637-55-3.mol
更新日期
2024/06/06 18:44:47
1700637-55-3 结构式
基本信息
中文别名
化合物CD38 INHIBITOR 14-((反式-4-(2-甲氧基乙氧基)环己基)氨基)-1-甲基-6-(噻唑-5-基)喹啉-2(1H)-酮
英文别名
cd38-1CD38 inhibitor 1
CD38 inhibitor 78c
CD38 inhibitor 1 (compound 78c)
CD38 inhibitor 1,Inhibitor,inhibit,CD-38 inhibitor 1
4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone
4-((trans-4-(2-Methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one
2(1H)-Quinolinone, 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-
所属类别
生物化工：抑制剂CD38 inhibitor 价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-123999 | CD38 inhibitor CD38 inhibitor 1 | 1700637-55-3 | 1mg | 600元 |
| 2024/04/30 | HY-123999 | CD38 inhibitor CD38 inhibitor 1 | 1700637-55-3 | 10mM * 1mLin DMSO | 1370元 |
| 2024/04/30 | S8960 | CD38 inhibitor CD38 inhibitor 1 (compound 78c) | 1700637-55-3 | 5mg | 1470元 |
常见问题列表
生物活性
CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553)是一种有效的 CD38 抑制剂，对人CD38和小鼠CD38的IC50分别为7.3 nM和1.9 nM。靶点
| Target | Value |
|
mCD38
(Cell-free assay) | 1.9 nM |
|
hCD38
(Cell-free assay) | 7.3 nM |
体内研究
CD38 inhibitor (30 mg/kg; oral administration; 2 and 6 hours) significantly elevates NAD levels in liver and muscle.
| Animal Model: | Diet induced obese (DIO) C57Bl6 mice |
| Dosage: | 30 mg/kg |
| Administration: | Orally once |
| Result: | NAD levels were significantly increased at both the 2 and 6 h time points in liver and muscle. |