251293-28-4
中文名称
UROTENSIN II (HUMAN)
英文名称
UROTENSIN II (HUMAN)
CAS
251293-28-4
分子式
C64H85N13O18S2
分子量
1388.57
MOL 文件
251293-28-4.mol
更新日期
2024/05/24 13:17:51
251293-28-4 结构式
基本信息
中文别名
硬骨鱼紧张肽IIH-GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL-OH(DISULFIDE BRIDGE:CYS5-CYS10)
英文别名
UTS2Urotensin-2
U-II (huMan)
UROTENSIN II (HUMAN)
Urotensin II, human (3)
Urotensin II (114-124), human
M.W. 1388.57 C64H85N13O18S2
Urotensin II human, ≥97% (HPLC)
UROTENSIN II (HUMAN) HYDROCHLORIDE
ETPDCFWKYCV, HCL (DISULFIDE BRIDGE: 5-10)
物理化学性质
储存条件-15°C
溶解度H2OPeptide Solubility and Storage Guidelines:1.??Calculate the length of the peptide.2.??Calculate the overall charge of the entire peptide according to the following table:3.??Recommended solution:
形态固体
水溶解性Soluble to 1 mg/ml in water
常见问题列表
生物活性
Urotensin II (114-124), human 是一个含 11 个氨基酸的残基肽，是孤儿受体 GPR14 激动剂，是一有效血管收缩剂。靶点
GPR14
体外研究
Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC 50 =0:62±0.17 nM, n=6).
体内研究
Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction.