375345-95-2
中文名称
MIBAMPATOR
英文名称
MibaMpator
CAS
375345-95-2
分子式
C21H30N2O4S2
分子量
438.6
MOL 文件
375345-95-2.mol
更新日期
2024/05/23 20:39:44
375345-95-2 结构式
基本信息
中文别名
化合物 T15820化合物MIBAMPATOR
英文别名
CS-1234LY 451395
MibaMpator
MIBAMPATOR
LY 451395
LY-451395
2-Propanesulfonamide, N-[(2R)-2-[4'-[2-[(methylsulfonyl)amino]ethyl][1,1'-biphenyl]-4-yl]propyl]-
[(2R)-2-[4-[4-[2-[(Methylsulfonyl)amino]ethyl]phenyl]phenyl]propyl][(1-methylethyl)sulfonyl]amine
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点609.4±65.0 °C(Predicted)
密度1.205±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)11.05±0.40(Predicted)
形态粉末
常见问题列表
生物活性
Mibampator (LY451395)是AMPA受体高选择性增强剂。靶点
AMPA receptor.
体内研究
Incubation of Mibampator (LY451395) with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species [1]. LY404187 and Mibampator (LY451395) reverses the central effects of an acutely intoxicating dose of ethanol in the rat. Mibampator (LY451395) significantly and dose-dependently reversed ethanol-induced deficits in both motor coordination and disruptions in an operant task where animals were trained to press a lever for food reward [2].