484049-04-9
中文名称
5-(3-(4-氟苯基)-1-苯基-1H-吡唑-4-基)咪唑烷-2,4-二酮
CAS
484049-04-9
分子式
C18H13FN4O2
分子量
336.32
MOL 文件
484049-04-9.mol
484049-04-9 结构式
基本信息
中文别名
5-(3-(4-氟苯基)-1-苯基-1H-吡唑-4-基)咪唑烷-2,4-二酮 英文别名
104868DPH >=98% (HPLC)
5-(1,3-diaryl-1H-pyrazol-4-yl)hydantoin
5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2,4-imidazolidinedione
5-(3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)imidazolidine-2,4-dione
2,4-Imidazolidinedione, 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-
常见问题列表
生物活性
DPH 是一种有效的，细胞渗透的 c-Abl 激活剂，在酶和细胞活动中，能够有效刺激 c-Abl 的活化。体外研究
DPH binds to the myristoyl binding site and prevents the formation of the bent conformation of the αI helix through steric hindrance, a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site. DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation.