524-81-2
中文名称
甲苯咔啉
英文名称
5-BENZYL-2-METHYL-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE
CAS
524-81-2
分子式
C19H20N2
分子量
276.38
MOL 文件
524-81-2.mol
524-81-2 结构式
基本信息
中文别名
甲苯咔啉 英文别名
MEBHYDROLINMebhydroline
N-Methyl-9-benzyltetrahydro-γ-carboline
3-Benzyl-6-methyl-1,2,3,4-tetrahydro-gamma-carboline
5-benzyl-2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole
5-benzyl-1,2,3,4-tetrahydro-2-methylpyrido(4,3-b)indole
5-Benzyl-1,3,4,5-tetrahydro-2-methyl-2H-pyrido[4,3-b]indole
5-BENZYL-2-METHYL-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE
2,3,4,5-Tetrahydro-2-methyl-5-phenylmethyl-1H-pyrido[4,3-b]indole
2,3,4,5-Tetrahydro-2-methyl-5-(phenylmethyl)-1H-pyrido[4,3-b]indole
物理化学性质
熔点95°
沸点bp1 207-215°
密度1.0246 (rough estimate)
折射率1.5640 (estimate)
储存条件-20°C储存
溶解度DMSO : 83.33 mg/mL (301.51 mM)
酸度系数(pKa)pKa 2.55 ± 0.18;7.63± 0.04(H2O,t undefined,I=0.30(NaCl)) (Uncertain)
常见问题列表
生物活性
Mebhydrolin 是一种特异性组胺 H1 受体拮抗剂。靶点
Histamine H1-receptor
体外研究
Mebhydrolin is a specific histamine H 1 -receptor antagonist with minimal sedative properties and comparing it with the effects of chlorpromazine, the archetypical phenothiazine. Mebhydrolin exerts an antihistaminic effect over the period of the ethanol interaction study.