55986-43-1
中文名称
西他苯
英文名称
CETABEN
CAS
55986-43-1
分子式
C23H39NO2
分子量
361.56
MOL 文件
55986-43-1.mol
更新日期
2023/02/22 11:54:00
55986-43-1 结构式
基本信息
中文别名
西他苯 英文别名
CETABENPeroxisome Proliferator, Cetaben
Benzoic acid, 4-(hexadecylamino)-
HEXADECYLAMINO-P-AMINO BENZOIC ACID
物理化学性质
沸点503.4±33.0 °C(Predicted)
密度0.979±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
酸度系数(pKa)4.76±0.10(Predicted)
形态结晶固体
西他苯价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-119964 | 西他苯 Cetaben | 55986-43-1 | 5mg | 500元 |
| 2024/04/30 | HY-119964 | 西他苯 Cetaben | 55986-43-1 | 10mM * 1mLin DMSO | 550元 |
| 2024/04/30 | HY-119964 | 西他苯 Cetaben | 55986-43-1 | 10mg | 800元 |
常见问题列表
生物活性
Cetaben 是一种不依赖 PPARα 的过氧化物酶体增殖物。Cetaben 是一种非纤维化降血脂药，可有效降低胆固醇和甘油三酸酯的浓度。体外研究
Cetaben (10 µM; 24 hours) induces severe micromorphological and ultrastructural changes in HepG2 and MH1C1 cells. After treatment with 100 µM cetaben, cells contained several Golgi regions, most of them disintegrated into vesicles.
Cetaben-treated (10 µM; 24 hours) cells were characterized by a striking heterogeneity of the peroxisomal population with the occurrence of dumbbell-shaped and cup-shaped peroxisomal profiles in MH1C1cells.
体内研究
Cetaben reveales a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect is observed at 250 mg/kg.
| Animal Model: | Male Wistar rats |
| Dosage: | 10,25,50,100,250 and 500 mg/kg |
| Administration: | Gavage; 10 day |
| Result: | Revealed a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect was observed at 250 mg/kg. |