6453-67-4

中文名称焦脱镁叶绿酸Α甲酯

CAS 6453-67-4

分子式 C34H36N4O3

分子量 548.67

MOL 文件 6453-67-4.mol

更新日期 2023/03/20 15:41:25

6453-67-4 结构式

基本信息物理化学性质安全数据焦脱镁叶绿酸Α甲酯价格(试剂级) 常见问题列表

基本信息

中文别名

叶绿素杂质5
焦脱镁叶绿酸Α甲酯
焦脱镁叶绿酸A甲酯杂质
焦脱镁叶绿酸-ALPHA 甲酯

英文别名

MPP A
PMPCA
INPP5E
KIAA0123
Nsc267052
Chlorophyll Impurity 5
Methyl pyropheophorbide a
Methyl pyrophaeophorbide a
Methyl carbamic pyrophyllate a
PYROPHEOPHORBIDE A METHYL ESTER

物理化学性质

沸点937.4±65.0 °C(Predicted)

密度1.219±0.06 g/cm3(Predicted)

储存条件−20°C

安全数据

WGK Germany3

焦脱镁叶绿酸Α甲酯价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-137473	焦脱镁叶绿酸Α甲酯 Methyl pyropheophorbide-a	6453-67-4	5 mg	900元
2024/04/30	HY-137473	焦脱镁叶绿酸Α甲酯 Methyl pyropheophorbide-a	6453-67-4	25 mg	2800元
2024/04/30	HY-137473	焦脱镁叶绿酸Α甲酯 Methyl pyropheophorbide-a	6453-67-4	100 mg	7200元

常见问题列表

生物活性

Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester)，叶绿素 a 的衍生物，是一种有效的光敏剂，可用于癌症的光动力疗法 (PDT)。Methyl pyropheophorbide-a 具有光动力学活性，可以诱导细胞凋亡并抑制肿瘤的生长。

体外研究

Pyropheophorbide-a methyl ester (2 μM; 12 h) inhibits the cell cycle progression from the G0/G1-phases and induces apoptosis at the light dosage of 55.6 kJ/m ² in PC-3M cells.
Pyropheophorbide-a methyl ester (0.2-15 μM; 20 h) has no signiﬁcant dark cytotoxicity in NCI-h446 cells.
Pyropheophorbide-a methyl ester (0.1-15 μM; 20 h) mediates a dose-dependent photocytotoxicity in the NCI-h446 cells.
Pyropheophorbide-a methyl ester (2-4 μM; 0-24 h) induces apoptosis of NCI-h446 cells in a time-dependent manner.
Pyropheophorbide-a methyl ester (0.5-4 μM; 0-20 h) shows a photocytotoxicity in PC-3M cells.

Apoptosis Analysis

Cell Line:	PC-3M cells
Concentration:	2 μM
Incubation Time:	12 h
Result:	Apoptosis rate was about 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 h posttreatment, respectively under the conditions of LC ₇₅ (2 μM+55.6 kJ/m ² ).

体内研究

Pyropheophorbide-a methyl ester (15 mg/kg; tail vein and topical injection) inhibits the growth of PC-3M tumors in mice.

Animal Model:	Male BALB/c nude mice (6-8 weeks, 16-20 g) bearing PC-3M tumor
Dosage:	15 mg/kg
Administration:	Tail vein injection and topical injection
Result:	The tumor volume and the weight inhibition rate were 46.78%, 41.84% in tail vein injection group and 78.66%, 72.07% in topical injection group, respectively.