72596-74-8
72596-74-8 结构式
基本信息
中文别名
化合物 T28348 英文别名
PD 404,1823,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
常见问题列表
生物活性
PD 404182 是一种有效的、竞争性的人类二甲基精氨酸二甲基氨基水解酶 1 (DDAH1) 抑制剂，IC50 值为 9 μM。PD 404182 在体外表现出抗血管生成和抗病毒活性。靶点
IC50: 9 μM (DDAH1)
体外研究
PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs.
PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity.
PD 404182 inhibits HIV-1 in seminal plasma, with an IC
50
of 1 μM.
PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD
4+
T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora.
Cell Viability Assay
| Cell Line: | Human dermal microvascular endothelial cells (ECs) |
| Concentration: | 10-300 μM |
| Incubation Time: | 24 hours |
| Result: | Did not induce cytotoxicity. |