84605-18-5
中文名称
环黄芪醇
英文名称
cycloastragenol
CAS
84605-18-5
分子式
C30H50O5
分子量
490.71
MOL 文件
84605-18-5.mol
更新日期
2024/05/30 11:29:21
84605-18-5 结构式
基本信息
中文别名
环黄芪宁环黄芪醇
三萜环黄氏醇
环黄芪醇对照品,
环黄芪醇, >98%
环黄芪醇(三萜环黄氏醇)
CYCLOASTRAGENOL 环黄芪醇
环黄芪醇,CYCLOASTRAGENOL
相关CAS号:78574-94-4,90865-25-1,104112-00-7
英文别名
CyclogalegeninCyclogalagenin
Cycloastrageno
cycloastragenol
Cyclogalgeginin
Cyclogalegigenin
Cycloastragenol, >98%
Cycloastragenol (Cyclogalagenin
84605-18-5 Cycloastragenol Plant Extract Powder
CYCLOGALAGENIN
CYCLOGALEGENIN
CYCLOGALEGIGENIN
物理化学性质
外观性状来源于豆科植物蒙古黄芪 Astragalus membranaceus （Fisch.） Bge. var. mongholicus （Bge.）Hsiao干燥根
熔点>220°C (dec.)
沸点617.2±55.0 °C(Predicted)
密度1.20
储存条件Refrigerator
溶解度可溶于氯仿（微量）、甲醇（微量）、吡啶（微量）
酸度系数(pKa)14.57±0.29(Predicted)
形态固体
颜色白色
常见问题列表
生物活性
Cycloastragenol 是一种天然的四环三萜类化合物，在筛选黄芪提取物时鉴定出具有抗衰老活性。Cycloastragenol 是一种有效的端粒酶 (telomerase) 激活剂。Cycloastragenol 还具有其他药理作用，包括抗炎和抗氧化特性。靶点
| Target | Value |
|
telomerase
() |
体外研究
Cycloastragenol (0-10 µM; 3-6 days) increases cell growth compared to the vehicle control in HEK cultures. Cycloastragenol (0.3 µM; 5-90 mins) induces CREB phosphorylation in primary cortical neurons, total CREB expression is unaltered by CAG in both cell type.Cycloastragenol (3 µM; 6-48 hours) may promotes prosurvival signaling in neurons, increases tert mRNA expression, exhibits increased bcl2 mRNA expression.
Cell Viability Assay
| Cell Line: | HEK cells |
| Concentration: | 1 µM, 3 µM, 10 µM |
| Incubation Time: | 3-6 days |
| Result: | Doubled the cell growth at 6 days. |
Western Blot Analysis
| Cell Line: | Neuronal cells |
| Concentration: | 0-3 µM |
| Incubation Time: | 5 mins, 15 mins, 30 mins, 90 mins |
| Result: | Suggested that CAG induces CREB activation in neuronal cells. |
Western Blot Analysis
| Cell Line: | Neuronal cells |
| Concentration: | 0-3 µM |
| Incubation Time: | 6-48 hours |
| Result: | Increased tert, bcl2 mRNA expression. |