881851-50-9
基本信息
90%)
LARAZOTIDE ACETATE (> 90%)
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/04/30 | HY-106268A | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH Larazotide acetate | 881851-50-9 | 1mg | 700元 |
2024/04/30 | HY-106268A | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH Larazotide acetate | 881851-50-9 | 5mg | 1100元 |
2024/04/30 | HY-106268A | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH Larazotide acetate | 881851-50-9 | 10mM * 1mLin Water | 1556元 |
常见问题列表
Paracellular permeability
Larazotide acetate inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Further, apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.
When tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice, larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure.