99697-24-2
中文名称
熊去氧胆酸杂质24
CAS
99697-24-2
分子式
C23H38O4
分子量
378.55
MOL 文件
99697-24-2.mol
更新日期
2024/02/17 22:13:20
99697-24-2 结构式
基本信息
中文别名
24-去甲氧基胆酸24-去甲熊去氧胆酸(NOR-UDCA)
化合物24-NORURSODEOXYCHOLIC ACID
英文别名
nor-UDCANorursodeoxycholic Acid
24-norursodeoxycholic acid
3α,7β-Dihydroxy-24-nor-5β-cholan-23-oic Acid
(3α,5β,7β)-3,7-Dihydroxy-24-norcholan-23-oic Acid
常见问题列表
生物活性
24-norursodeoxycholic acid (norUDCA) 是侧链缩短的 UDCA 的 C23 同系物，具有有效的抗胆汁淤积，抗炎和抗纤维化特性。体外研究
24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and is previously shown to be highly effective in preclinical mouse models of cholestatic and fibrotic liver diseases. 24-norursodeoxycholic acid significantly reduces serum alkaline phosphatase (ALP) levels in a dose-dependent fashion. 24-norursodeoxycholic acid also significantly reduces γ-GT, ALT, and AST serum levels.