CS-1211
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- CAS号:
- 229961-45-9
- 英文名:
- AGN 194310
- 英文别名:
- AGN;CS-1211;VTP194310;VTP-194310;AGN 194310;VTP 194310;AGN-194310, 194310;AGN194310; AGN-194310; VTP194310; VTP 194310; VTP-194310;Benzoic acid, 4-[2-[4-(4-ethylphenyl)-2,2-dimethyl-2H-1-benzothiopyran-6-yl]ethynyl]-
- 中文名:
- CS-1211
- 中文别名:
- 化合物 T14143;RAR激动剂(AGN194310)
- CBNumber:
- CB01346990
- 分子式:
- C28H24O2S
- 分子量:
- 424.55
- MOL File:
- 229961-45-9.mol
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CS-1211化学性质
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沸点:
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598.1±50.0 °C(Predicted)
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密度:
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1.26±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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>16.8mg/mL in DMSO
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形态:
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Powder
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酸度系数(pKa):
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4.02±0.10(Predicted)
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CS-1211性质、用途与生产工艺
AGN 194310 (VTP-194310) 是一种高亲和力的、有效的、具有选择性的视黄酸受体 (RARs) 的泛拮抗剂，对 RARα，RARβ，RARγ 的 Kd 值分别为 3 nM，2 nM，5 nM。
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RARα
3 nM (Kd)
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RARβ
2 nM (Kd)
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RARγ
5 nM (Kd)
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AGN194310 potently inhibits colony formation by all three lines, with IC50 values of 16 nM for LNCaP cells; 18 nM for PC3 cells; and 34 nM for DU-145 cells.
AGN 194310 (50 nM, 100 nM; LNCaP, PC-3 and DU-145 cells) inhibits colony formation at concentrations of 50 nM and 100 nM alone and in combination with TTNPB.
AGN 194310 (1 μM; 72 hours; LNCaP cells) treatment results in 80% apoptosis.
Cell Viability Assay
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Cell Line:
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LNCaP, PC-3 and DU-145 cells.
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Concentration:
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50 nM, 100 nM
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Incubation Time:
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Result:
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When used together with 100 nM TTNPB, there was almost complete reversal of the growth inhibitory effect of 50 nM and partial reversal of the effect of 100 nM.
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Apoptosis Analysis
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Cell Line:
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LNCaP cells
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Concentration:
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1 μM
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Incubation Time:
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72 hours
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Result:
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Induced apoptosis in LNCaP cells.
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AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment increases the number of granulocytes across haemopoietic compartments. A significant increase in the frequency of granulocyte-progenitor cells is observed in the bone marrow of mice after treatment with AGN194310.
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Animal Model:
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Female C57Bl/6J mice (Five-week-old (34-37 days))
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Dosage:
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0.5 mg/kg/day
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Administration:
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Oral gavage; every day; for 10 days
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Result:
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The number of granulocytes was significantly increased across haemopoietic compartments. Progenitor cells containing granulocytes also increased significantly.
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CS-1211
上下游产品信息
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-16681 | CS-1211
AGN 194310 | 229961-45-9 | 1mg | 1200元 |
| 2024/04/30 | HY-16681 | CS-1211
AGN 194310 | 229961-45-9 | 5mg | 4500元 |
229961-45-9, CS-1211 相关搜索:
- 细胞生物学试剂
- 化合物 T14143
- RAR激动剂(AGN194310)
- 229961-45-9
- Benzoic acid, 4-[2-[4-(4-ethylphenyl)-2,2-dimethyl-2H-1-benzothiopyran-6-yl]ethynyl]-
- AGN
- VTP-194310
- VTP194310
- VTP 194310
- AGN194310; AGN-194310; VTP194310; VTP 194310; VTP-194310
- CS-1211
- AGN-194310, 194310
- AGN 194310