化合物 T16570
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- CAS号:
- 192755-52-5
- 英文名:
- (3S,11S)-N-[(2R,3S)-2-ethoxy-5-oxo-oxolan-3-yl]-3-(isoquinoline-1-carbonylamino)-2,6-dioxo-1,7-diazabicyclo[5.4.0]undecane-11-carboxamide
- 英文别名:
- VX-740;HMR 3480;Pralnacasan;(3S,11S)-N-[(2R,3S)-2-ethoxy-5-oxo-oxolan-3-yl]-3-(isoquinoline-1-carbonylamino)-2,6-dioxo-1,7-diazabicyclo[5.4.0]undecane-11-carboxamide;(1S,9S)-N-[(2R,3S)-2-Ethoxy-5-oxotetrahydro-3-furanyl]-9-[(1-isoquinolinylcarbonyl)amino]-6,10-dioxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxamide;6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxamide, N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]octahydro-9-[(1-isoquinolinylcarbonyl)amino]-6,10-dioxo-, (1S,9S)-
- 中文名:
- 化合物 T16570
- 中文别名:
- 化合物 T16570
- CBNumber:
- CB01484119
- 分子式:
- C26H29N5O7
- 分子量:
- 523.54
- MOL File:
- 192755-52-5.mol
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化合物 T16570化学性质
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密度:
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1.44±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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酸度系数(pKa):
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10.80±0.40(Predicted)
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化合物 T16570性质、用途与生产工艺
Pralnacasan (VX-740) 是一种有效的，选择性的，非肽型，具有口服活性白介素 1β 转化酶 (ICE, caspase 1) 抑制剂，Ki 为 1.4 nM。Pralnacasan 抑制促炎细胞因子 IL-18，IL-1β 和 IFN-γ。Pralnacasan 有潜力用于骨关节炎和类风湿关节炎的研究。
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Interleukin-1β converting enzyme
1.4 nM (Ki)
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Pralnacasan (0 -50 mg/kg; oral gavage; twice a day; for 6 weeks; female Balb/c mice) treatment reduces joint damage. Pralnacasan treatment does not appear to affect the weight of the animals.
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Animal Model:
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Female Balb/c mice induced with collagenase
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Dosage:
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0 mg/kg, 12.5 mg/kg, 25 mg/kg and 50 mg/kg
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Administration:
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Oral gavage; twice a day; for 6 weeks
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Result:
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Significantly ameliorated the histopathological damage of the medial knee joint compartments.
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化合物 T16570
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-19676 | 化合物 T16570
Pralnacasan | 192755-52-5 | 1mg | 5200元 |
192755-52-5, 化合物 T16570 相关搜索:
- C26H29N5O7
- 化合物 T16570
- 192755-52-5
- 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxamide, N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]octahydro-9-[(1-isoquinolinylcarbonyl)amino]-6,10-dioxo-, (1S,9S)-
- VX-740
- Pralnacasan
- HMR 3480
- (1S,9S)-N-[(2R,3S)-2-Ethoxy-5-oxotetrahydro-3-furanyl]-9-[(1-isoquinolinylcarbonyl)amino]-6,10-dioxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxamide
- (3S,11S)-N-[(2R,3S)-2-ethoxy-5-oxo-oxolan-3-yl]-3-(isoquinoline-1-carbonylamino)-2,6-dioxo-1,7-diazabicyclo[5.4.0]undecane-11-carboxamide