原卟啉二氯化锡(IV)
|
|
|
- CAS号:
- 14325-05-4
- 英文名:
- TIN PROTOPORPHYRIN IX DICHLORIDE
- 英文别名:
- SnPPIX;Nsc267099;TINPROTOPORPHYRIN;Tin protoporphyrin I;tin protoporphyrin IX;TIN PROTOPORPHYRIN IX DICHLORIDE;Tin Protoporphyrin IX (chloride);Tinprotoporphyrin IX,Tin protoporphyrin IX;Tin Protoporphyrin IX dichloride (NSC 267099;Stannate(2-) dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid]
- 中文名:
- 原卟啉二氯化锡(IV)
- 中文别名:
- 锡原卟啉IX;原卟啉二氯化锡;化合物 T13161;锡原卟啉IX二氯乙烷;原卟啉二氯化锡(IV);原卟啉IX二氯化锡(IV);锡(IV) 卟啉 IX 二氯
- CBNumber:
- CB0148951
- 分子式:
- C34H36Cl2N4O4Sn
- 分子量:
- 754.29
- MOL File:
- 14325-05-4.mol
|
|
|
原卟啉二氯化锡(IV)化学性质
-
储存条件:
-
Store at RT
-
|
-
溶解度:
-
Soluble to 25 mM in 1eq. NaOH and to 5 mM in DMSO
-
|
-
形态:
-
Dark red to violet solid.
-
|
原卟啉二氯化锡(IV)性质、用途与生产工艺
Tin-protoporphyrin IX (SnPPIX) 是有效的血红素加氧酶-1 (HO-1) 抑制剂。 Tin-protoporphyrin IX (SnPPIX) 使 PDAC 管腺癌肿瘤对化疗敏感。
IC50: Heme oxygenase-1 (HO-1)
Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM.
Cell Viability Assay
|
Cell Line:
|
Capan-1, CD18/HPAF, PDAC cells
|
|
Concentration:
|
20 μM, 50 μM
|
|
Incubation Time:
|
24 or 72 hours
|
|
Result:
|
Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM.
|
Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment.
|
Animal Model:
|
Male and female athymic nude mice with PDAC cell-derived xenograft tumors
|
|
Dosage:
|
5 mg/kg
|
|
Administration:
|
Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20
|
|
Result:
|
Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).
|
原卟啉二氯化锡(IV)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101194 | 原卟啉二氯化锡(IV)
Tin-protoporphyrin IX | 14325-05-4 | 5mg | 2500元 |
| 2024/04/30 | HY-101194 | 原卟啉二氯化锡(IV)
Tin-protoporphyrin IX | 14325-05-4 | 10mg | 3200元 |
14325-05-4, 原卟啉二氯化锡(IV) 相关搜索:
- Porphyrins
- C34H32Cl2N4O4Sn
- 原卟啉二氯化锡
- 原卟啉IX二氯化锡(IV)
- 化合物 T13161
- 锡原卟啉IX
- 锡(IV) 卟啉 IX 二氯
- 原卟啉二氯化锡(IV)
- 锡原卟啉IX二氯乙烷
- 14325-05-4
- Tinprotoporphyrin IX,Tin protoporphyrin IX
- Tin Protoporphyrin IX dichloride (NSC 267099
- Tin protoporphyrin I
- SnPPIX
- TIN PROTOPORPHYRIN IX DICHLORIDE
- Tin Protoporphyrin IX (chloride)
- Stannate(2-) dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid]
- Nsc267099
- TINPROTOPORPHYRIN
- tin protoporphyrin IX