1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide

生物活性靶点体外研究体内研究

CAS号:: 1610022-76-8

英文名:: 1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide

英文别名:: Nrf2 inhibitor 1;1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl);1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide;inhibit,Acute,leukemia,AML,myeloid,Nrf2,Inhibitor,Nrf2IN1,Keap1-Nrf2,Nrf-2-IN-1,Nrf2 IN 1;3-(4-Chlorophenyl)-1-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-hydroxy-1H-pyrazole-5-carboxamide;1H-Pyrazole-5-carboxamide, 3-(4-chlorophenyl)-1-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-hydroxy-

中文名:: 1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide

中文别名:: 化合物NRF2-IN-1

CBNumber:: CB03353619

分子式:: C21H22ClN3O2

分子量:: 383.87

MOL File:: 1610022-76-8.mol

化学性质安全信息用途供应商 14

1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide化学性质

密度:: 1.23±0.1 g/cm3(Predicted)

储存条件:: Store at -20°C

溶解度:: DMSO: 260 mg/mL (677.31 mM)

酸度系数(pKa):: 8.44±0.50(Predicted)

安全信息

1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide性质、用途与生产工艺

生物活性

Nrf2-IN-1 是 Nrf2 的抑制剂，被用于急性髓性白血病 (AML) 药物研究。

Nrf2-IN-1 (Compound 4f) (10 μM) inhibits Nrf2 activation.
Nrf2-IN-1(1-20 μM; 48 hours) inhibits growth of the three AML cell.
Nrf2-IN-1 (5-10 μM; 48 hours) induces apoptosis of three AML cells in vitro.
Nrf2-IN-1 induces apoptotic signaling involving Bcl-2 and Bax.

Cell Viability Assay

Cell Line:	THP-1 cells, HL-60 cells, U937 cells
Concentration:	1 μM, 5 μM, 10 μM, 20 μM
Incubation Time:	48 hours
Result:	Inhibited growth of the three AML cell types at 5 μM, 10 μM or 20 μM for 48 hours.

Apoptosis Analysis

Cell Line:	THP-1 cells, HL-60 cells, U937 cells
Concentration:	5 μM, 10 μM
Incubation Time:	48 hours
Result:	Induced apoptosis in AML cells in vitro.

Western Blot Analysis

Cell Line:	THP-1 cells, HL-60 cells, U937 cells
Concentration:	5 μM, 10 μM
Incubation Time:	48 hours
Result:	Triggered caspase-dependent apoptotic signaling in AML cells.

体内研究

Nrf2-IN-1 inhibits tumor growth via apoptosis in chicken eggs.

1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide 上下游产品信息

上游原料

下游产品

1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide 生产厂家

全球有 14家供应商 1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
上海奥晨生物医药科技有限公司	13917627064	56229367@qq.com	中国	565	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
ChemeGen 中国	18818260767	sales@chemegen.com	中国	11289	58
上海弘渠生物医药科技有限公司	88888888888	hongquchem@qq.com	中国	5132	58
成都超九八生物科技有限公司	13348960310 13348960310	3003867561@qq.com	中国	10011	58
天津普西唐生物医药科技有限公司	010-60605840	psaitong@jm-bio.com	中国	29778	58
开封明仁药业有限公司	0371-65741762	sales@hasunny.com	中国	2380	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24017	58
上海陌孚医药科技有限公司	021-59167510 18117107507	vip@med-life.cn	中国	5019	58
南京世洲生物科技有限公司	025-85560043 15850508050	cindy.huang@synzest.com	中国	12007	58
銳迪國際科技有限公司	18024082417	market@ubiochem.com	中国	9180	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	美国	52927	58

1610022-76-8, 1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide 相关搜索:

化合物NRF2-IN-1
1610022-76-8
inhibit,Acute,leukemia,AML,myeloid,Nrf2,Inhibitor,Nrf2IN1,Keap1-Nrf2,Nrf-2-IN-1,Nrf2 IN 1
1H-Pyrazole-5-carboxamide, 3-(4-chlorophenyl)-1-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-hydroxy-
Nrf2 inhibitor 1
3-(4-Chlorophenyl)-1-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-hydroxy-1H-pyrazole-5-carboxamide
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide