Z-ILE-LEU-ALDEHYDE
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- CAS号:
- 161710-10-7
- 英文名:
- GAMMA-SECRETASE INHIBITOR XII
- 英文别名:
- GSI-XII);Z-IL-CHO;Z-ILE-LEU-ALDEHYDE;γ-Secretase inhibitor XII;Z-Ile-Leu-aldehyde(Z-IL-CHO;GAMMA-SECRETASE INHIBITOR XII;γ-Secretase inhibitor XII (GSI-XII);Z-ILE-LEU-ALDEHYDE(Z-IL-CHO; GSI-XII);Z-IL-CHO;GSI-XII;Γ-SECRETASE INHIBITOR XII;Benzyl ((2S,3S)-3-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate
- 中文名:
- Z-ILE-LEU-ALDEHYDE
- 中文别名:
- GAMMA-SECRETASE抑制剂(Z-ILE-LEU-ALDEHYDE)
- CBNumber:
- CB0336194
- 分子式:
- C20H30N2O4
- 分子量:
- 362.46
- MOL File:
- 161710-10-7.mol
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Z-ILE-LEU-ALDEHYDE化学性质
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沸点:
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545.6±45.0 °C(Predicted)
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密度:
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1.074±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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insoluble in EtOH; insoluble in H2O; ≥10.8 mg/mL in DMSO
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形态:
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solid
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酸度系数(pKa):
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11.14±0.46(Predicted)
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Z-ILE-LEU-ALDEHYDE性质、用途与生产工艺
Z-Ile-Leu-aldehyde (Z-IL-CHO) 是有效的、竞争性的 γ-secretase 和 notch 的肽醛抑制剂。
Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays.
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity.
RT-PCRsup>[1]
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Cell Line:
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CD4
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T cells from C57BL/6 mice.
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Concentration:
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25 μM.
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Incubation Time:
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24, 48, 72 hours.
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Result:
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DownregulateD RORt and IL-17 mRNA expression.
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Cell Viability Assaysup>[2]
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Cell Line:
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MOPC315.BM cells.
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Concentration:
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0, 12, 15 μM.
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Incubation Time:
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24-48 h hours.
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Result:
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Reduced viability and induced apoptosis in MOPC315.BM cells
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Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment.
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Animal Model:
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MOPC315.BM mouse model.
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Dosage:
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10 mg/kg.
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Administration:
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Intraperitoneally either for 14 days.
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Result:
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Reduces myeloma-specific paraprotein levels in the MOPC315.BM model.
Diminished osteolytic lesions in the MOPC315.BM mice.
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Z-ILE-LEU-ALDEHYDE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12465 | Z-Ile-Leu-aldehyde | | 1 mg | 1600元 |
| 2024/04/30 | HY-12465 | Z-ILE-LEU-ALDEHYDE
Z-Ile-Leu-aldehyde | 161710-10-7 | 2mg | 2333元 |
161710-10-7, Z-ILE-LEU-ALDEHYDE 相关搜索:
- 细胞生物学试剂
- GAMMA-SECRETASE抑制剂(Z-ILE-LEU-ALDEHYDE)
- 161710-10-7
- γ-Secretase inhibitor XII
- γ-Secretase inhibitor XII (GSI-XII)
- GSI-XII)
- Z-Ile-Leu-aldehyde(Z-IL-CHO
- Z-ILE-LEU-ALDEHYDE(Z-IL-CHO; GSI-XII)
- Z-IL-CHO;GSI-XII;Γ-SECRETASE INHIBITOR XII
- Benzyl ((2S,3S)-3-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate
- Carbamic acid, N-[(1S,2S)-1-[[[(1S)-1-formyl-3-methylbutyl]amino]carbonyl]-2-methylbutyl]-, phenylmethyl ester
- GAMMA-SECRETASE INHIBITOR XII
- Z-IL-CHO
- Z-ILE-LEU-ALDEHYDE