SU 4312;NSC 86429;SU-4312;NSC-86429
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- CAS号:
- 5812-07-7
- 英文名:
- SU 4312
- 英文别名:
- SU 4312;NSC 86429;SU4312(NSC86429);SU 4312;NSC 86429;SU-4312;NSC-86429;3-(4-DIMETHYLAMINOBENZYLIDENYL)-2-INDOLINONE;(Z)-3-(4-(DIMETHYLAMINO)BENZYLIDENE)INDOLIN-2-ONE;3-[[(4-DIMETHYLAMINO)PHENYL]METHYLENE]-1,3-DIHYDRO-2H-INDOL-2-ONE;2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro;3-[[(4-Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture;PDGFR,Inhibitor,SU4312,VEGFR,inhibit,Vascular endothelial growth factor receptor,Platelet-derived growth factor receptor,SU-4312
- 中文名:
- SU 4312;NSC 86429;SU-4312;NSC-86429
- 中文别名:
- 化合物NSC 86429;SU4312,VEGFR和PDGFR受体酪氨酸激酶抑制剂;3-[[4-(二甲基氨基)苯基]亚甲基]-1,3-二氢-2H-吲哚-2-酮
- CBNumber:
- CB0444460
- 分子式:
- C17H16N2O
- 分子量:
- 264.32
- MOL File:
- 5812-07-7.mol
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SU 4312;NSC 86429;SU-4312;NSC-86429化学性质
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熔点:
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225-232 °C
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沸点:
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497.1±45.0 °C(Predicted)
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密度:
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1.219±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 30 mg/mL
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形态:
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Orange solid.
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酸度系数(pKa):
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12.89±0.20(Predicted)
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颜色:
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orange
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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SU 4312;NSC 86429;SU-4312;NSC-86429性质、用途与生产工艺
SU4312 是 (Z)-SU4312 和 (E)-SU4312 的外消旋体。(Z)-SU4312 抑制 PDGFR 和 FLK-1，IC50 分别为 19.4 和 0.8 μM。(E)-SU4312 抑制 PDGFR, FLK-1, EGFR, HER-2, 和 IGF-1R，IC50 分别为 24.2，5.2，18.5，16.9 和 10.0 μM。
Receptor tyrosine kinases (RTKs) have been shown to be important mediators of cellular signal transduction in cells. Many RTKs have been shown to be oncogene products implicating their role in the transformation process associated with human cancers.
SU 4312;NSC 86429;SU-4312;NSC-86429
上下游产品信息
上游原料
下游产品
SU 4312;NSC 86429;SU-4312;NSC-86429
生产厂家
5812-07-7, SU 4312;NSC 86429;SU-4312;NSC-86429 相关搜索:
3-(4-吗啉亚苄基)吲哚啉-2-酮 su5204 SU-14813 2-[(1,2-二氢-2-氧代-3H-吲哚-3-亚基)甲基]-4-甲基-1H-吡咯-3-丙酸 格尔德霉素 (3S,6S,12aS)-1,2,3,4,6,7,12,12a-八氢-9-甲氧基-6-(2-甲基丙基)-1,4-二氧代吡嗪并[1',2':1,6]吡啶并[3,4-b]吲哚-3-丙酸叔丁酯 S-三苯甲基-L-半胱氨酸 替拉替尼 NULL SU4313SU-4313SU4313 N/A SU4942;SU-4942;SU4942 N-(3-氯苯基)-N-甲基-3-[[3,5-二甲基-4-[(4-甲基哌嗪-1-基)羰基-1H-吡咯-2-基]亚甲基]-2-氧代-2,3-二氢-1H-吲哚-5-磺酰胺 SU5205;SU-5205;SU5205 (E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺 AAL-993
- Angiogenesis and Metastasis
- Protein Kinase
- Vascular Endothelial Growth Factor Receptor and Platelet-Derived Growth Factor Receptor (VEGFR1/2 and PDGFR)
- Kinase/Phosphatase Biology
- Receptor Tyrosine Kinase Inhibitors
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- 5812-7-7
- SU4312,VEGFR和PDGFR受体酪氨酸激酶抑制剂
- 化合物NSC 86429
- 3-[[4-(二甲基氨基)苯基]亚甲基]-1,3-二氢-2H-吲哚-2-酮
- 5812-07-7
- PDGFR,Inhibitor,SU4312,VEGFR,inhibit,Vascular endothelial growth factor receptor,Platelet-derived growth factor receptor,SU-4312
- SU 4312;NSC 86429;SU-4312;NSC-86429
- SU4312(NSC86429)
- (Z)-3-(4-(DIMETHYLAMINO)BENZYLIDENE)INDOLIN-2-ONE
- 2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro
- SU 4312
- NSC 86429
- 3-[[(4-Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture
- 3-(4-DIMETHYLAMINOBENZYLIDENYL)-2-INDOLINONE
- 3-[[(4-DIMETHYLAMINO)PHENYL]METHYLENE]-1,3-DIHYDRO-2H-INDOL-2-ONE