MIV-150
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- CAS号:
- 231957-54-3
- 英文名:
- MIV-150
- 英文别名:
- PC 815;MIV-150;MIV150,MIV 150;1-(5-cyanopyridin-2-yl)-3-[(1S,2S)-2-(6-fluoro-2-hydroxy-3-;Urea, N-(5-cyano-2-pyridinyl)-N'-[(1S,2S)-2-[6-fluoro-2-hydroxy-3-(1-oxopropyl)phenyl]cyclopropyl]-
- 中文名:
- MIV-150
- 中文别名:
- 化合物 T16081
- CBNumber:
- CB04666145
- 分子式:
- C19H17FN4O3
- 分子量:
- 368.36
- MOL File:
- 231957-54-3.mol
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MIV-150化学性质
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沸点:
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501.8±50.0 °C(Predicted)
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密度:
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1.41±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 30 mg/mL; DMSO: 30 mg/mL; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL; Ethanol: 0.25 mg/mL
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形态:
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A crystalline solid
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酸度系数(pKa):
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7.49±0.50(Predicted)
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MIV-150性质、用途与生产工艺
MIV-150 是 NNTR 的一个抑制剂，可以抑制 HIV-1 和 HIV-2 感染，其对 HIV-1/HIV-2 的 EC50 值为 <1 nM。
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HIV-1
<1 nM (EC
50
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HIV-2
<1 nM (EC
50
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The activity of MIV-150 to protect target cells from infection is assayed using a syncytial assay. The EC
50
of MIV-150 against HIV-1MN in CEM.SS cells is below 1 nM. These data are in agreement with the findings of Medivir. MIV-150 effectively inactivated free virus with an EC
50
of 0.004 μg/mL (or 0.01 μM). It is demonstrated MIV-150 is highly effective against HIV and that the drug blocks viruses that are resistant to other marketed HIV antiretrovirals such as Nevirapine, Delavirdine, and Efavirenz. In addition, resistance to MIV-150 develops more slowly than to other anti-HIV drugs tested. For example, in vitro studies demonstrate that resistance development in the presence of nevirapine and delavirdine takes only 4 to 5 weeks compared with 45 weeks in the presence of MIV-150.
MIV-150
上下游产品信息
上游原料
下游产品
231957-54-3, MIV-150 相关搜索:
- 化合物 T16081
- 231957-54-3
- Urea, N-(5-cyano-2-pyridinyl)-N'-[(1S,2S)-2-[6-fluoro-2-hydroxy-3-(1-oxopropyl)phenyl]cyclopropyl]-
- MIV150,MIV 150
- 1-(5-cyanopyridin-2-yl)-3-[(1S,2S)-2-(6-fluoro-2-hydroxy-3-
- PC 815
- MIV-150