ADU-S100 DISODIUM SALT
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- CAS号:
- 1638750-95-4
- 英文名:
- c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS
- 英文别名:
- ADUS100 sodium;ADU-S100
(MIW815);MIW815 disodium salt;ADU-S100 disodium salt;ML RR-S2 CDA Sodium Salt;ML RR-S2 CDA disodium salt;c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS;c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS;ADUS100 disodium salt,ADU S100 disodium salt,ADU-S-100 disodium salt
- 中文名:
- ADU-S100 DISODIUM SALT
- 中文别名:
- 化合物 T10252;ADU-S100二钠盐
- CBNumber:
- CB04670984
- 分子式:
- C20H25N10NaO10P2S2
- 分子量:
- 714.54
- MOL File:
- 1638750-95-4.mol
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ADU-S100 DISODIUM SALT化学性质
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储存条件:
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Store at -20°C
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水溶解性:
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Water: 100 mg/mL (136.15 mM; ultrasonic and adjust pH to 7 with NaOH)
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ADU-S100 DISODIUM SALT性质、用途与生产工艺
ADU-S100 disodium salt (MIW815 disodium salt) 是干扰素基因刺激物的激活剂 (STING)，具有有效的抗肿瘤和免疫活性。
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING
REF
and hSTING
Q
alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8
+
T cell responses, and improves long-term survival to 50%.
ADU-S100 DISODIUM SALT
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12885A | ADU-S100 DISODIUM SALT
ADU-S100 disodium salt | 1638750-95-4 | 1mg | 3300元 |
| 2023/03/20 | HY-12885A | ADU-S100 DISODIUM SALT
ADU-S100 disodium salt | 1638750-95-4 | 5mg | 12000元 |
ADU-S100 DISODIUM SALT
生产厂家
1638750-95-4, ADU-S100 DISODIUM SALT 相关搜索:
- Nucleotide
- 制剂-激动剂
- ADU-S100二钠盐
- 化合物 T10252
- 1638750-95-4
- c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS
- ADUS100 disodium salt,ADU S100 disodium salt,ADU-S-100 disodium salt
- ADUS100 sodium
- ML RR-S2 CDA Sodium Salt
- MIW815 disodium salt
- ML RR-S2 CDA disodium salt
- ADU-S100 disodium salt
- ADU-S100
(MIW815)
- c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS