SBi4211 dimethanesulfonate
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- CAS号:
- 161374-55-6
- 英文名:
- SBi4211 dimethanesulfonate
- 英文别名:
- SBi4211 dimethanesulfonate;Heptamidine dimethanesulfote;Heptamidine dimethanesulfonate;4,4'-(Heptane-1,7-diylbis(oxy))dibenzimidamide dimethanesulfonate;Heptamidine,dystrophy,SBi 4211,Myotonic,SBi4211,inhibit,Calcium-Binding,cancer,melanoma,SBi-4211,S100B,Heptamidine dimethanesulfonate,HeLa,Inhibitor,cell
- 中文名:
- SBi4211 dimethanesulfonate
- 中文别名:
- 二甲基磺酸庚胺;4,4'-(庚烷-1,7-二基双(氧基))二苯甲脒 二甲磺酸盐;化合物HEPTAMIDINE DIMETHANESULFONATE
- CBNumber:
- CB08054427
- 分子式:
- C22H32N4O5S
- 分子量:
- 464.58
- MOL File:
- 161374-55-6.mol
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SBi4211 dimethanesulfonate化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 62.5 mg/mL (111.47 mM)
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SBi4211 dimethanesulfonate性质、用途与生产工艺
Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) 是一种强效的，与喷他脒 (HY-B0537) 有关的钙结合蛋白 S100B 的抑制剂 (Kd=6.9 μM)，选择性地杀死表达 S100B 的黑素瘤细胞。Heptamidine dimethanesulfonate 是研究强直性肌营养不良 (DM) 的有效工具。
Kd: 6.9 μM (calcium-binding protein S100B)
Heptamidine is a Pentamidine-S100B complex, two molecules of pentamidine bind per monomer of S100B, which performs to be an inhibitor for S100B.Heptamidine (20 μM) does not decrease CUG levels significantly when compares to Propamidine and Pentamidine, and exhibits cytotoxic at concentrations above 17.5 μM in HeLa cells expressing 960 CUG repeats.Heptamidine rescues mis-splicing of minigene reporters in a HeLa cell DM1 model with an EC
50
value of 15 μM.
Heptamidine (intraperitoneal injection; 20 or 30 mg/kg; 7 days) causes a dose-dependent reduction of exon 7a inclusion in
HSA
LR mice, returning to wild type levels (6±1%) when at 20 mg/kg dose, the myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 or 30 mg/kg.
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Animal Model:
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Homozygous HSALR transgenic mice in line 20b (FVB inbred background) with a Myotonic dystrophy (DM) mouse model
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Dosage:
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20 or 30 mg/kg
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Administration:
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Intraperitoneal injection; 7 days; once daily
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Result:
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Reversed splicing defects and rescues myotonia in a DM mouse model.
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SBi4211 dimethanesulfonate
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-16918A | SBi4211 dimethanesulfonate
Heptamidine dimethanesulfonate | 161374-55-6 | 5mg | 2100元 |
| 2024/04/30 | S3389 | SBi4211 dimethanesulfonate
Heptamidine Dimethanesulfonate | 161374-55-6 | 5mg | 2366.91元 |
SBi4211 dimethanesulfonate
生产厂家
161374-55-6, SBi4211 dimethanesulfonate 相关搜索:
- 药靶配体
- 二甲基磺酸庚胺
- 4,4'-(庚烷-1,7-二基双(氧基))二苯甲脒 二甲磺酸盐
- 化合物HEPTAMIDINE DIMETHANESULFONATE
- 161374-55-6
- Heptamidine,dystrophy,SBi 4211,Myotonic,SBi4211,inhibit,Calcium-Binding,cancer,melanoma,SBi-4211,S100B,Heptamidine dimethanesulfonate,HeLa,Inhibitor,cell
- 4,4'-(Heptane-1,7-diylbis(oxy))dibenzimidamide dimethanesulfonate
- SBi4211 dimethanesulfonate
- Heptamidine dimethanesulfote
- Heptamidine dimethanesulfonate