溴法罗明
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- CAS号:
- 63638-91-5
- 英文名:
- Brofaromine
- 英文别名:
- 4-(7-bromo-5-methoxybenzofuran-2-yl)piperidine;Piperidine, 4-(7-bromo-5-methoxy-2-benzofuranyl)-;4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine
- 中文名:
- 溴法罗明
- 中文别名:
- 化合物 T10617
- CBNumber:
- CB11178149
- 分子式:
- C14H16BrNO2
- 分子量:
- 310.19
- MOL File:
- 63638-91-5.mol
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溴法罗明化学性质
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沸点:
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404.0±45.0 °C(Predicted)
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密度:
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1.386±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (805.96 mM)
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酸度系数(pKa):
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9.99±0.10(Predicted)
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溴法罗明性质、用途与生产工艺
Brofaromine (CGP 11305A) 是一种单胺氧化酶 (MAO) 抑制剂，抑制 MAO-A，IC50 为 0.2 μM。
In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC
50
is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC
50
range of Brofaromine is 0.01 μM to 0.1 μM.
溴法罗明
上下游产品信息
上游原料
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63638-91-5, 溴法罗明 相关搜索:
- 化合物 T10617
- 63638-91-5
- Piperidine, 4-(7-bromo-5-methoxy-2-benzofuranyl)-
- 4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine
- 4-(7-bromo-5-methoxybenzofuran-2-yl)piperidine