3-(溴乙酸酰基)丙酸琥珀酰亚胺酯
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- CAS号:
- 57159-62-3
- 英文名:
- N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE
- 英文别名:
- SBAP;SKL289;SUCCINIMIDYL 3-[BROMOACETAMIDO]PROPIONATE;N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE;SucciniMidyl 3-(broMoacetaMido)propionate(SBAP);Succinimidyl 3-(bromoacetamido)propionate≥ 98% (HPLC);2,5-dioxopyrrolidin-1-yl 3-(2-bromoacetamido)propanoate;β-Alanine, N-(2-bromoacetyl)-, 2,5-dioxo-1-pyrrolidinyl ester;2-BroMo-N-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]acetaMide
- 中文名:
- 3-(溴乙酸酰基)丙酸琥珀酰亚胺酯
- 中文别名:
- 3-(溴乙酸酰基)丙酸琥珀酰亚胺酯;3-(溴乙酰胺基)琥珀酰亚胺基丙酸酯;琥珀酰亚胺基 3-(溴乙酰氨基)丙酸酯;2,5-二氧代吡咯烷-1-基 3-(2-溴乙酰氨基)丙酸酯;2,5-DIOXOPYRROLIDIN-1-YL 3-(3-BROMOACETAMIDO)PROPANOATE
- CBNumber:
- CB1123003
- 分子式:
- C9H11BrN2O5
- 分子量:
- 307.1
- MOL File:
- 57159-62-3.mol
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3-(溴乙酸酰基)丙酸琥珀酰亚胺酯化学性质
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熔点:
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93-94°C
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密度:
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1.69±0.1 g/cm3(Predicted)
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储存条件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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Chloroform (Slightly, Heated), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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12.96±0.46(Predicted)
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颜色:
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Off-White to White Waxy
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CAS 数据库:
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57159-62-3
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3-(溴乙酸酰基)丙酸琥珀酰亚胺酯性质、用途与生产工艺
N-Succinimidyl 3-(Bromoacetamido)propionate 是一种 PROTAC linker，属于 PEG 类。可用于合成PROTAC分子。N-Succinimidyl 3-(Bromoacetamido)propionate 也是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联药物 (ADC)。
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PEGs
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Alkyl/ether
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Cleavable
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
3-(溴乙酸酰基)丙酸琥珀酰亚胺酯
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57159-62-3, 3-(溴乙酸酰基)丙酸琥珀酰亚胺酯 相关搜索:
- MTS & Sulfhydryl Active Reagents
- Cross Linking Reagents
- MTS and Sulfhydryl Active Reagents
- 高端化学
- 3-(溴乙酰胺基)琥珀酰亚胺基丙酸酯
- 2,5-二氧代吡咯烷-1-基 3-(2-溴乙酰氨基)丙酸酯
- 2,5-DIOXOPYRROLIDIN-1-YL 3-(3-BROMOACETAMIDO)PROPANOATE
- 琥珀酰亚胺基 3-(溴乙酰氨基)丙酸酯
- 3-(溴乙酸酰基)丙酸琥珀酰亚胺酯
- 57159-62-3
- SKL289
- β-Alanine, N-(2-bromoacetyl)-, 2,5-dioxo-1-pyrrolidinyl ester
- 2,5-dioxopyrrolidin-1-yl 3-(2-bromoacetamido)propanoate
- Succinimidyl 3-(bromoacetamido)propionate≥ 98% (HPLC)
- N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE
- SUCCINIMIDYL 3-[BROMOACETAMIDO]PROPIONATE
- SBAP
- SucciniMidyl 3-(broMoacetaMido)propionate(SBAP)
- 2-BroMo-N-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]acetaMide