158089-95-3
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- CAS号:
- 158089-95-3
- 英文名:
- S-2474
- 英文别名:
- S-2474;S 2474,S2474;2,6-ditert-butyl-4-[(2-ethyl-1,1-dioxo-1,2-thiazolidin-5-ylidene)methyl]phenol;Phenol, 2,6-bis(1,1-dimethylethyl)-4-[(E)-(2-ethyl-1,1-dioxido-5-isothiazolidinylidene)methyl]-
- 中文名:
- 158089-95-3
- 中文别名:
- 化合物 T16817
- CBNumber:
- CB13175582
- 分子式:
- C20H31NO3S
- 分子量:
- 365.53
- MOL File:
- 158089-95-3.mol
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158089-95-3化学性质
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熔点:
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135-137 °C
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沸点:
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462.7±55.0 °C(Predicted)
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密度:
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1.129±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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11.28±0.50(Predicted)
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158089-95-3性质、用途与生产工艺
S-2474 是 COX-2 和 5-lipoxygenase (5-LO) 的抑制剂,在人完整的细胞中,对 COX-2 和 COX-1 的 IC50 值分别为 11 nM 和 27 μM,为一种非甾体抗炎药。
COX-2
11 nM (IC
50
)
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COX-1
27 μM (IC
50
)
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5-LO
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S-2474 is an inhibitor of COX-2 and 5-lipoxygenase, with IC
50
s of 11 nM and 27 μM for COX-2 and COX-1. S-2474 prevents neurons from Aβ-induced cell death significantly in a concentration-dependent manner (IC
50
=26±12 nM). S-2474 (10 μM) completely inhibits Aβ(25-35)-induced neuronal cell death. S-2474 also shows neuroprotective effects in the Aβ(1-40)-induced neuronal cell death. S-2474 inhibits the PGD2 generation in a concentration dependent manner (IC
50
=69.8±21.9 nM). S-2474 (10 μM) lowers the elevated level of PGD2 significantly and reduces radicals from Aβ(25-35)-treated neurons. S-2474 significantly prevents neurons from undergoing sPLA
2
-IIA-induced cell death. S-2474 completely ameliorates sPLA
2
-IIA-induced apoptotic features such as the condensation of chromatin and the fragmentation of DNA. Moreover, S-2474 significantly inhibits the sPLA
2
-IIA-induced generation of PGD2. S-2474 inhibits sPLA
2
-IIA-induced neuronal cell death in a concentration-dependent manner (IC
50
= 94 nM).
158089-95-3
上下游产品信息
上游原料
下游产品
158089-95-3, 158089-95-3 相关搜索:
- 化合物 T16817
- 158089-95-3
- S 2474,S2474
- Phenol, 2,6-bis(1,1-dimethylethyl)-4-[(E)-(2-ethyl-1,1-dioxido-5-isothiazolidinylidene)methyl]-
- 2,6-ditert-butyl-4-[(2-ethyl-1,1-dioxo-1,2-thiazolidin-5-ylidene)methyl]phenol
- S-2474