关附壬素
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- CAS号:
- 110225-59-7
- 英文名:
- Hetisan-2,11,13,14-tetrol,2-acetate, (2a,11a,13R)-
- 英文别名:
- Hetisan-2,11,13,14-tetrol,2-acetate, (2a,11a,13R)-;Hetisan-2,11,13,14-tetrol, 2-acetate, (2α,11α,13R)-
- 中文名:
- 关附壬素
- 中文别名:
- 关附壬素
- CBNumber:
- CB13179858
- 分子式:
- C22H29NO5
- 分子量:
- 387.48
- MOL File:
- 110225-59-7.mol
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关附壬素化学性质
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沸点:
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551.8±50.0 °C(Predicted)
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密度:
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1.48±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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13.30±0.70(Predicted)
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关附壬素性质、用途与生产工艺
Guanfu base I (Acorine) 是 Guanfu base A 的活性代谢产物，是从 Aconitum coreanum 中分离得到的，具有很强的抗心律失常的作用。
The pharmacokinetics of Guanfu base I in Sprague-Dawley rats is examined. The method is linear in the 0.05-20 μg/mL concentration range. The recovery of Guanfu base I is more than 80%. The intraday and interday precision, expressed as the relative standard deviation, is generally good. After intravenous injection dosing, plasma Guanfu base I concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 hours. The total plasma clearance value is 1.46 L/h/kg. After oral dosing, the plasma Guanfu base I concentration reached a maximum within 0.5 hour. The absolute bioavailability of Guanfu base I is 71.31%.
关附壬素
上下游产品信息
上游原料
下游产品
110225-59-7, 关附壬素 相关搜索:
- 生物碱
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- 关附壬素
- 110225-59-7
- Hetisan-2,11,13,14-tetrol, 2-acetate, (2α,11α,13R)-
- Hetisan-2,11,13,14-tetrol,2-acetate, (2a,11a,13R)-