ML-9 FREE BASE
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- CAS号:
- 110448-31-2
- 英文名:
- ML-9
- 英文别名:
- ML-9 Free Base;ML9 Free Base,ML 9 Free Base;1H-1,4-Diazepine, 1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-
- 中文名:
- ML-9 FREE BASE
- 中文别名:
- 化合物 T16103
- CBNumber:
- CB13303040
- 分子式:
- C15H17ClN2O2S
- 分子量:
- 324.83
- MOL File:
- 110448-31-2.mol
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ML-9 FREE BASE化学性质
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沸点:
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508.8±60.0 °C(Predicted)
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密度:
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1.327±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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9.74±0.20(Predicted)
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ML-9 FREE BASE性质、用途与生产工艺
ML-9 (Free Base) 是 Akt 激酶的选择性强效抑制剂，可抑制肌球蛋白轻链激酶 (MLCK) 和基质相互作用分子 1 (STIM1) 的活性。 ML-9 (Free Base) 抑制 MLCK，PKA 和 PKC 活性，Ki 值分别为 4、32 和 54 μM。 ML-9 通过刺激自噬小体的形成并抑制其降解来诱导自噬 (autophagy)。
ML9 (Free Base) (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death.
ML9 (Free Base) (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%.
Cell Viability Assay
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Cell Line:
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Neonatal rat ventricular myocytes (NRVM) cells
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Concentration:
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0, 10, 50 and 100 μM
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Incubation Time:
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0, 1, 4, 8 and 24 hours
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Result:
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Decreased cell viability at 50–100 μM concentration.
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Apoptosis Analysis
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Cell Line:
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Neonatal rat ventricular myocytes (NRVM) cells
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Concentration:
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50 μM
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Incubation Time:
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0, 1, 4, 8 hours
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Result:
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Induced cardiomyocyte death through necrosis and apoptosis.
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ML-9 FREE BASE
上下游产品信息
上游原料
下游产品
110448-31-2, ML-9 FREE BASE 相关搜索:
- 化合物 T16103
- 110448-31-2
- 1H-1,4-Diazepine, 1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-
- ML9 Free Base,ML 9 Free Base
- ML-9 Free Base