116308-56-6
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- CAS号:
- 116308-56-6
- 英文名:
- Watanipidine monohydrochloride
- 英文别名:
- AE0047 Hydrochloride;Watanipidine monohydrochloride;AE0047 Hydrochloride,AE-0047 Hydrochloride
- 中文名:
- 116308-56-6
- 中文别名:
- 化合物 T13328
- CBNumber:
- CB13339728
- 分子式:
- C41H43ClN4O6
- 分子量:
- 723.25632
- MOL File:
- 116308-56-6.mol
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116308-56-6化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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116308-56-6性质、用途与生产工艺
AE0047 Hydrochloride 是一种 calcium 阻滞剂，可用于高血压症的研究。
AE0047 Hydrochloride (4e) is a calcium antagonist. AE0047 inhibits [
3
H]nimodipine binding to rat cardiac membrane homogenate with an IC
50
of 0.26 nM. AE0047 (1 μM) inhibits the high K
+
-evoked vascular smooth muscle contraction, and also inhibits [
3
H]PN200-110 binding with a K
i
of 40.9 nM.
AE0047 (3 mg/kg) shows antihypertensive effect, and reduces systolic blood pressure with ED
30
of 1.1 mg/kg. AE0047 (1 or 3 mg/25g SP diet) inhibits blood pressure elevation and improves endothelium-dependent relaxation in response to acetylcholine in aorta isolated from stroke-prone spontaneously hypertensive rats (SHRSP).
116308-56-6
上下游产品信息
上游原料
下游产品
116308-56-6, 116308-56-6 相关搜索:
- 化合物 T13328
- 116308-56-6
- AE0047 Hydrochloride,AE-0047 Hydrochloride
- AE0047 Hydrochloride
- Watanipidine monohydrochloride