3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide

生物活性靶点体外研究

CAS号:: 363571-83-9

英文名:: 3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide

英文别名:: 3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide;3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide;Benzoic acid, 3,5-dibromo-4-hydroxy-, 2-[[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylene]hydrazide

中文名:: 3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide

中文别名:: 化合物 T15663;KINESORE,KINESIN-1调节剂

CBNumber:: CB13707372

分子式:: C20H16Br2N4O4

分子量:: 536.17

MOL File:: 363571-83-9.mol

化学性质安全信息用途供应商 14

3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide化学性质

密度:: 1.71±0.1 g/cm3(Predicted)

储存条件:: Store at -20°C

溶解度:: DMSO : 125 mg/mL (233.14 mM)

酸度系数(pKa):: 5.43±0.25(Predicted)

安全信息

3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide性质、用途与生产工艺

Remarkably, in kinesore-treated cells, the microtubule network is entirely reorganized into a series of loops and bundles. In addition, the lysosomal compartment accumulates in a juxtanuclear position, where there are relatively few microtubules. At 50 μM kinesore, this phenotype is highly penetrant, with 95±2.4% (n=3, total of 200 cells) of cells exhibiting a reorganized nonradial microtubule network. In titration experiments, in cells treated for 1 h, this phenotype becomes apparent at a concentration of 25 μM kinesore, with relatively little effect at or below concentrations of 12.5 μM. The effect is reversible because a 2-h washout of kinesore from cells treated for 1 h led to the reestablishment of the radial microtubule array. This kinesore-induced reorganization of the microtubule network is observed in a panel of mammalian normal and cancer cell lines. In wild-type cells, 50 μM kinesore induces the remodeling of the microtubule network and the formation of extensive microtubule-rich projections. This phenotype is strongly suppressed in Kif5B knockout cells, confirming that microtubule remodeling induced by kinesore is dependent upon the presence of kinesin-1.

3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide 上下游产品信息

上游原料

下游产品

3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide 生产厂家

全球有 14家供应商 3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
天津凯利奇生物科技有限公司	15076683720	klq@cw-bio.com	中国	3500	55
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
上海源溪生物科技有限公司	021-58447131 13564518121	sales@dcchemicals.com	中国	9414	58
ChemeGen 中国	18818260767	sales@chemegen.com	中国	11289	58
上海弘渠生物医药科技有限公司	88888888888	hongquchem@qq.com	中国	5132	58
天津普西唐生物医药科技有限公司	010-60605840	psaitong@jm-bio.com	中国	29778	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24017	58
南通全益生物科技有限公司	0513-66337626 18051384581	sales@chemhifuture.com	中国	4209	58
南京世洲生物科技有限公司	025-85560043 15850508050	cindy.huang@synzest.com	中国	12007	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	美国	52927	58

363571-83-9, 3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide 相关搜索:

KINESORE,KINESIN-1调节剂
化合物 T15663
363571-83-9
Benzoic acid, 3,5-dibromo-4-hydroxy-, 2-[[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylene]hydrazide
3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide
3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide