170365-25-0
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- CAS号:
- 170365-25-0
- 英文名:
- KW-8232 free base
- 英文别名:
- KW-8232 free base;KW8232 free base,KW 8232 free base;Methanone, [3-[bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl][4-(2-chlorophenyl)-1-piperazinyl]-
- 中文名:
- 170365-25-0
- 中文别名:
- 化合物 T11792
- CBNumber:
- CB14796665
- 分子式:
- C36H37ClN4O3
- 分子量:
- 609.16
- MOL File:
- 170365-25-0.mol
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170365-25-0化学性质
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沸点:
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805.5±65.0 °C(Predicted)
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密度:
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1.26±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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9.95±0.10(Predicted)
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170365-25-0性质、用途与生产工艺
KW-8232 free base 是一种抗骨质疏松剂，可以减少前列腺素 PGE2 的生物合成。
KW-8232 free base is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE
2
in mouse osteoblastic cells.
KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production.
170365-25-0
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100304 | 170365-25-0
KW-8232 free base | 170365-25-0 | 1mg | 8500元 |
170365-25-0, 170365-25-0 相关搜索:
- C36H37ClN4O3
- 化合物 T11792
- 170365-25-0
- KW8232 free base,KW 8232 free base
- Methanone, [3-[bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl][4-(2-chlorophenyl)-1-piperazinyl]-
- KW-8232 free base