245747-71-1
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- CAS号:
- 245747-71-1
- 英文名:
- NFAT Transcription Factor Regulator
- 英文别名:
- NFAT Transcription Factor Regulator;NFAT Transcription Factor Regulator-1;NFAT Transcription Factor Regulator 1,NFAT Transcription Factor Regulator1;N-(4-(5-(Difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide;4-Pyridinecarboxamide, N-[4-[5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-
- 中文名:
- 245747-71-1
- 中文别名:
- 化合物 T12218;NFAT转录因子调节剂-1;N-(4-(5-(二氟甲氧基)-3-(三氟甲基)-1H-吡唑-1-基)苯基)-3-氟异烟酰胺
- CBNumber:
- CB14797086
- 分子式:
- C17H10F6N4O2
- 分子量:
- 416.28
- MOL File:
- 245747-71-1.mol
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245747-71-1化学性质
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沸点:
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408.4±45.0 °C(Predicted)
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密度:
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1.53±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 150 mg/mL (360.33 mM);Water : < 0.1 mg/mL (insoluble)
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酸度系数(pKa):
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9.85±0.70(Predicted)
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245747-71-1性质、用途与生产工艺
NFAT Transcription Factor Regulator-1 是 IL-2 合成 的抑制剂，IC50 值为182 nM。
NFAT Transcription Factor Regulator-1 (compound example 19) inhibits IL-2 synthesis with an IC
50
of 182 nM. NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC
50
s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release.
NFAT Transcription Factor Regulator-1 is found to have an inhibitory potency approximately 10-fold better than that of cyclosporine. Comparable inhibitory effects on T-cell IL-2 production are obtained with NFAT Transcription Factor Regulator-1 and cyclosporine at doses of 3.0 and 30 mg/kg, po, respectively. The efficacies achieved in monkeys
in vivo
for blocking T-cell cytokine production suggest that NFAT Transcription Factor Regulator-1 has potential similar to that of cyclosporine for use in transplantation.
245747-71-1
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-112778 | NFAT Transcription Factor Regulator-1 | | 1 mg | 666元 |
| 2024/04/30 | HY-112778 | 245747-71-1
NFAT Transcription Factor Regulator-1 | 245747-71-1 | 5mg | 1750元 |
245747-71-1, 245747-71-1 相关搜索:
- N-(4-(5-(二氟甲氧基)-3-(三氟甲基)-1H-吡唑-1-基)苯基)-3-氟异烟酰胺
- NFAT转录因子调节剂-1
- 化合物 T12218
- 245747-71-1
- N-(4-(5-(Difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide
- NFAT Transcription Factor Regulator 1,NFAT Transcription Factor Regulator1
- 4-Pyridinecarboxamide, N-[4-[5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-
- NFAT Transcription Factor Regulator-1
- NFAT Transcription Factor Regulator