568544-03-6
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- CAS号:
- 568544-03-6
- 英文名:
- 2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE
- 英文别名:
- GSTO1-IN-1;GSTO1 inhibitor 1;2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE;2-Chloro-N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)acetamide;2-Chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]acetamide;Acetamide, 2-chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]-;GSTs,GSTO1IN1,Glutathione transferases,inhibit,Inhibitor,Gutathione S-transferase,GSTO1 IN 1,GSTO-1-IN-1
- 中文名:
- 568544-03-6
- 中文别名:
- 化合物GSTO1-IN-1;2-氯-N-(4-氯-3-(N,N-二甲基氨磺酰)苯基)乙酰胺
- CBNumber:
- CB1774579
- 分子式:
- C10H12Cl2N2O3S
- 分子量:
- 311.18
- MOL File:
- Mol file
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568544-03-6化学性质
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储存条件:
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under inert gas (nitrogen or Argon) at 2–8 °C
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568544-03-6性质、用途与生产工艺
GSTO1-IN-1 是一种有效的谷胱甘肽 S-转移酶 omega 1 (GSTO1) 抑制剂，IC50 为 31 nM。
GSTO1-IN-1 (C1-27) potently inhibits GSTO1 enzyme activity with an IC
50
value of 31 nM. GSTO1-IN-1 also potently competes with 5-chloromethylfluorescein diacetate (CMFDA) for binding to recombinant protein, as well as endogenous GSTO1 in the milieu of a soluble proteome. HCT116 cells treated with GSTO1-IN-1 also show a decrease in cell viability in a dose-dependent manner. GSTO1-IN-1 inhibits the clonogenic survival of HCT116 cells at sub-micromolar concentrations.
To test whether GSTO1-IN-1 had in vivo efficacy, its effects are evaluated in a human colon cancer cell line xenograft model. GSTO1-IN-1 (20-45 mg/kg) is administered as a single agent to nude mice bearing HCT116 xenografts. After 5 weeks of treatment, tumor growth is significantly inhibited in GSTO1-IN-1-treated mice compared with the vehicle-treated group (P<0.05). GSTO1-IN-1 treatment is generally well tolerated by mice up to 45 mg/kg, with no overt signs of toxicity and no significant variations in average body weights throughout the duration of the study.
568544-03-6
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-111530 | GSTO1-IN-1 | | 5 mg | 937元 |
| 2024/04/30 | HY-111530 | 568544-03-6
GSTO1-IN-1 | 568544-03-6 | 10mg | 1500元 |
568544-03-6, 568544-03-6 相关搜索:
- 化合物GSTO1-IN-1
- 2-氯-N-(4-氯-3-(N,N-二甲基氨磺酰)苯基)乙酰胺
- 568544-03-6
- GSTs,GSTO1IN1,Glutathione transferases,inhibit,Inhibitor,Gutathione S-transferase,GSTO1 IN 1,GSTO-1-IN-1
- 2-Chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]acetamide
- GSTO1-IN-1
- 2-Chloro-N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)acetamide
- Acetamide, 2-chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]-
- GSTO1 inhibitor 1
- 2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE