SMS2-IN-1
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- CAS号:
- 2098890-15-2
- 英文名:
- SMS2-IN-1
- 英文别名:
- JUN90152;SMS2-IN-1;SMS2 IN 1,SMS2IN1,SMS-2-IN-1;1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-[3-[[3-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl]-1,2-dihydro-1-methyl-2-oxo-4-quinolinyl]oxy]propyl]-, 1-methylcyclopropyl ester
- 中文名:
- SMS2-IN-1
- 中文别名:
- 化合物 T12938;化合物SMS2-IN-1
- CBNumber:
- CB18054545
- 分子式:
- C34H37F6N3O5
- 分子量:
- 681.67
- MOL File:
- 2098890-15-2.mol
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SMS2-IN-1化学性质
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沸点:
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685.7±55.0 °C(Predicted)
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密度:
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1.37±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 27.78 mg/mL (40.75 mM; Need ultrasonic)
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酸度系数(pKa):
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-1.20±0.20(Predicted)
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SMS2-IN-1性质、用途与生产工艺
SMS2-IN-1 是一种高选择性的鞘磷脂合成酶 2 (SMS2) 抑制剂，其 IC50 为 6.5 nM，Kd 为 37 nM。SMS2-IN-1 对 SMS2 的选择性是 SMS1 (IC50 为 1000 nM) 的 150 倍。
IC50: 6.5 nM (SMS2), 1000 nM (SMS1)
Kd: 37 nM (SMS2)
AS/MS binding experiments are conducted using these SMS2-mutant membrane fractions, SMS2-IN-1 (compound 2) binds to the S217A, H272A, and D276A mutants. S227 and H229 are pivotal amino acid residues for the binding of SMS2-IN-1 to SMS2.
SMS2-IN-1
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-102041 | SMS2-IN-1 | | 1 mg | 1714元 |
| 2024/04/30 | HY-102041 | SMS2-IN-1
SMS2-IN-1 | 2098890-15-2 | 5mg | 4500元 |
2098890-15-2, SMS2-IN-1 相关搜索:
- 化合物SMS2-IN-1
- 化合物 T12938
- 2098890-15-2
- 1-Piperidinecarboxylic acid, 4-[3-[[3-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl]-1,2-dihydro-1-methyl-2-oxo-4-quinolinyl]oxy]propyl]-, 1-methylcyclopropyl ester
- SMS2 IN 1,SMS2IN1,SMS-2-IN-1
- JUN90152
- 1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
- SMS2-IN-1