137338-43-3
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- CAS号:
- 137338-43-3
- 英文名:
- LAS 31180
- 英文别名:
- LAS 31180;LAS 31180,LAS31180;Methanesulfonamide, N-(1,4-dihydro-1-methyl-4-oxo-3-quinolinyl)-
- 中文名:
- 137338-43-3
- 中文别名:
- 化合物 T15714
- CBNumber:
- CB21360640
- 分子式:
- C11H12N2O3S
- 分子量:
- 252.29
- MOL File:
- 137338-43-3.mol
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137338-43-3化学性质
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沸点:
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386.7±52.0 °C(Predicted)
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密度:
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1.42±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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5.70±0.20(Predicted)
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137338-43-3性质、用途与生产工艺
LAS-31180 是一种 phosphodiesterase 3 的抑制剂，能够增强肌肉收缩和血管舒张。
LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC
50
of 1.2 mumol/L) and in isolated guinea-pig working hearts.
In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure.
137338-43-3
上下游产品信息
上游原料
下游产品
137338-43-3, 137338-43-3 相关搜索:
- 化合物 T15714
- 137338-43-3
- LAS 31180,LAS31180
- Methanesulfonamide, N-(1,4-dihydro-1-methyl-4-oxo-3-quinolinyl)-
- LAS 31180