Ro 64-6198
|
|
- CAS号:
- 280783-56-4
- 英文名:
- Ro 64-6198
- 英文别名:
- Ro 64-6198;Ro 64-6198 >=98% (HPLC);1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-
- 中文名:
- Ro 64-6198
- 中文别名:
- 化合物 T16772
- CBNumber:
- CB21386123
- 分子式:
- C26H31N3O
- 分子量:
- 401.54
- MOL File:
- 280783-56-4.mol
|
|
|
Ro 64-6198化学性质
-
沸点:
-
626.2±55.0 °C(Predicted)
-
|
-
密度:
-
1.25±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
酸度系数(pKa):
-
15.03±0.20(Predicted)
-
|
Ro 64-6198性质、用途与生产工艺
Ro 64-6198 是一种有效的,选择性的,非肽,高亲和力,高细胞通透性和脑渗透 N/OFQ 受体 (NOP) 激动剂,EC50 值为 25.6 nM。Ro 64-6198 对 NOP 受体的选择性至少是经典阿片受体的 100 倍。Ro 64-6198 可用于压力和焦虑,成瘾,神经性疼痛,咳嗽和厌食症的研究。
Ro 64-6198 also produces rapid desensitization of the NOP receptor. In vitro studies shows that treatment with Ro 64-6198 results in a functional desensitization of the receptor, a loss in binding sites, and an apparent decrease in binding affinity. The desensitization produced by Ro 64-6198 is not reversed by acidic washes.
Ro 64-6198 does recruit both arrestin3 (
EC
50
of 0.912 µM) and arrestin2 (
EC
50
of 1.20 µM) to the NOP receptor in a concentration-dependent manner comparably with N/OFQ.
At low doses Ro 64-6198 is anxiolytic in several neophobic tests, including the marble burying test in mice, the elevated plus maze in rats and the open field test in rats. In the marble burying test, at 1 mg/kg, i.p., Ro 64-6198 produces a decrease in the number of marbles buried, without altering locomotor activity, indicating a decrease in neophobia and anxiety. Ro 64-6198 selectively increases the number of open arm transitions and time spent in the open arms of the elevated plus maze at doses of 0.32-3 mg/kg, i.p., without affecting closed arm transitions or locomotor activity in the closed arms. In the open field test, Ro 64-6198, at doses of 0.32-3 mg/kg, attenuates the inhibition of exploration that results from the stress of a novel environment.
Ro 64-6198
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-12844 | Ro 64-6198 Ro 64-6198 | 280783-56-4 | 1mg | 1600元 |
2024/04/30 | HY-12844 | Ro 64-6198 Ro 64-6198 | 280783-56-4 | 10mM * 1mLin DMSO | 4240元 |
280783-56-4, Ro 64-6198 相关搜索:
- 化合物 T16772
- 280783-56-4
- 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-
- Ro 64-6198 >=98% (HPLC)
- Ro 64-6198