157263-00-8
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- CAS号:
- 157263-00-8
- 英文名:
- MK 996
- 英文别名:
- MK 996;L-159282;Benzamide, N-[[4'-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl][1,1'-biphenyl]-2-yl]sulfonyl]-
- 中文名:
- 157263-00-8
- 中文别名:
- CBNumber:
- CB21389124
- 分子式:
- C30H28N4O3S
- 分子量:
- 524.63
- MOL File:
- 157263-00-8.mol
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157263-00-8化学性质
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密度:
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1.27±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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4.70±0.10(Predicted)
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157263-00-8性质、用途与生产工艺
L-159282 是一种有效的，可口服的，非肽段的 angiotensin II receptor 拮抗剂，具有抗高血压的功效。
In the anesthetized chimpanzee, L-159282 (1 mg/kg, iv) produces 100% inhibition of the AII pressor response and is still active (52%) at 24 h. In aortic coarcted (high renin) rats, L-159282 (3 mg/kg, p.o.) reduces blood pressure to normotensive (< 120 mm Hg) levels without reflex tachycardia. This dose of L-159282 reduces blood pressure to approximately the same level as both losartan (3 mg/kg, p.o.) and enalapril (3 mg/kg, p.o.) in this model.
157263-00-8
上下游产品信息
上游原料
下游产品
157263-00-8, 157263-00-8 相关搜索:
- 157263-00-8
- Benzamide, N-[[4'-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl][1,1'-biphenyl]-2-yl]sulfonyl]-
- L-159282
- MK 996