RO 15-4513
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- CAS号:
- 91917-65-6
- 英文名:
- RO 15-4513
- 英文别名:
- RO 15-4513;Azidomazenil;Ro15 4513,Ro154513,Ro-15-4513;RO 15-4513 ETHANOL ANTAGONIST;Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate;ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE;8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester;4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester;8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER;4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
- 中文名:
- RO 15-4513
- 中文别名:
- 化合物 T16775
- CBNumber:
- CB2312745
- 分子式:
- C15H14N6O3
- 分子量:
- 326.32
- MOL File:
- 91917-65-6.mol
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RO 15-4513化学性质
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储存条件:
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Desiccate at +4°C
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溶解度:
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45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL
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形态:
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solid
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颜色:
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tan
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CAS 数据库:
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91917-65-6
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RO 15-4513性质、用途与生产工艺
Ro15-4513 是咪唑并苯二氮酮衍生物，是苯二氮卓受体 (BZR) 的部分反向激动剂。Ro15-4513 是有效的乙醇 (ethanol) 拮抗剂。Ro15-4513 具有抗焦虑作用。
Ro15-4513 usually acts as a partial inverse agonist at GABA
A
receptors, except an agonist for α4 and α6 subunit-containing ones.
Ro 15-4513 (i.p.; 3 mg/kg; 10 min before being tested) completely inhibits the ethanol-induced (1.8 g/kg) reduction in total locomotor activity and partly the reduction in rearing.
Ro 15-4513 (i.p.; 3 mg/kg; 15 min before administration of 1.5 g/kg ethanol) reverses ethanol-induced sedation in GABA
A
receptor δ subunit-deficient mice.
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Animal Model:
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Male C57BL/6J mice
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Dosage:
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3 mg/kg
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Administration:
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I.p.; 10 min before being tested
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Result:
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Completely inhibited the ethanol-induced reduction in total locomotor activity and partly the reduction in rearing.
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RO 15-4513
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-103476 | RO 15-4513
Ro15-4513 | 91917-65-6 | 1mg | 710元 |
| 2024/04/30 | HY-103476 | RO 15-4513
Ro15-4513 | 91917-65-6 | 5mg | 1350元 |
91917-65-6, RO 15-4513 相关搜索:
- GABA/Glycine receptor
- Chemical Ligation
- Specialty Synthesis
- Organic Azides
- Click Chemistry
- C15H14N6O3
- 化合物 T16775
- 91917-65-6
- Ro15 4513,Ro154513,Ro-15-4513
- RO 15-4513 ETHANOL ANTAGONIST
- Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate
- 4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
- Ethyl 8-azido-6-dihyro-5-methyl-6-oxo-4H-imidazo[1,5-A][1,4]benzodiazepine-3-carboxylic acid ethyl ester
- Azidomazenil
- 8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
- 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester
- ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE
- 8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER
- RO 15-4513