141335-10-6
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- CAS号:
- 141335-10-6
- 英文名:
- LCB-2853
- 英文别名:
- LCB 2853,LCB2853;Benzeneacetic acid, 4-[[1-[[[(4-chlorophenyl)sulfonyl]amino]methyl]cyclopentyl]methyl]-
- 中文名:
- 141335-10-6
- 中文别名:
- 化合物 T11825
- CBNumber:
- CB23175549
- 分子式:
- C21H24ClNO4S
- 分子量:
- 421.94
- MOL File:
- 141335-10-6.mol
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141335-10-6化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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141335-10-6性质、用途与生产工艺
LCB-2853 是 thromboxane A2 受体的拮抗剂,具有抗血小板和抗血栓的作用。
In dog coronary stenosis, LCB 2853 shows a very high efficacy with ED
50
of 7.2 μg/kg. In rat venous thrombosis induced by combination of venous injury and blood stasis, perfused LCB 2853 decreases the weight of thrombi in a dose related manner with ED
50
of 220 μg/kg/min. In vivo, both against platelet aggregation and vasoconstriction, LCB 2853 shows an ED
50
lower than 1 mg/kg i.v. in rat AA-induced thrombocytopenia or U 46619-induced hypertension (ED
50
= 0.25 and 0.16 mg/kg) as well as in AA-induced sudden death in the mouse (ED
50
= 0.44 mg/kg). The U 46619-induced bronchoconstriction is blocked after i.v. administration of LCB 2853 (ED
50
= 18.4 μg/kg).
141335-10-6
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141335-10-6, 141335-10-6 相关搜索:
- 化合物 T11825
- 141335-10-6
- LCB 2853,LCB2853
- Benzeneacetic acid, 4-[[1-[[[(4-chlorophenyl)sulfonyl]amino]methyl]cyclopentyl]methyl]-