氯苯氨啶
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- CAS号:
- 7761-45-7
- 英文名:
- Metoprine
- 英文别名:
- DDMP;U-197;BW 197U;SK 5265;NSC 7364;NSC-19494;BW-50-197;Metoprine;methodichlorophen;2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE
- 中文名:
- 氯苯氨啶
- 中文别名:
- 氯苯氨啶;5-(3,4-二氯苯基)-6-甲基嘧啶-2,4-二胺
- CBNumber:
- CB31179180
- 分子式:
- C11H10Cl2N4
- 分子量:
- 269.13
- MOL File:
- 7761-45-7.mol
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氯苯氨啶化学性质
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熔点:
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275-276℃
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沸点:
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418.42°C (rough estimate)
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密度:
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1.447
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折射率:
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1.6300 (estimate)
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储存条件:
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Hygroscopic, Refrigerator, under inert atmosphere
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溶解度:
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DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated)
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形态:
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Solid
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酸度系数(pKa):
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6.80±0.10(Predicted)
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颜色:
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Off-White to Light Yellow
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稳定性:
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Hygroscopic
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氯苯氨啶性质、用途与生产工艺
Metoprine (BW 197U) 是一种有效的组胺 N-甲基转移酶 (HMT) 抑制剂。Metoprine 是一种二氨基嘧啶衍生物，可以透过血脑屏障，并通过抑制 HMT 增加脑组胺水平。Metoprine 是一种抗叶酸 (antifolate) 和抗肿瘤药。
Metoprine (BW 197U; 2-10 mg/kg; IP) ameliorates the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner.
Intraperitoneal administration of Metoprine produces various behavioral effects, including decreases in food intake and increases in water consumption.
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Animal Model:
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Male Sprague-dawley rats (200-280g)
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Dosage:
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2, 5, 10 mg/kg
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Administration:
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IP
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Result:
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Ameliorated the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner and significanty prolonged transfer latency at a high dose of 10 mg/kg.
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氯苯氨啶
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-129441 | Metoprine | | 5 mg | 687元 |
| 2024/04/30 | HY-129441 | 氯苯氨啶
Metoprine | 7761-45-7 | 10mg | 1100元 |
7761-45-7, 氯苯氨啶 相关搜索:
- Pharmaceuticals
- Nucleotides
- Intermediates & Fine Chemicals
- Heterocycles
- Bases & Related Reagents
- 氯苯氨啶
- 5-(3,4-二氯苯基)-6-甲基嘧啶-2,4-二胺
- 7761-45-7
- 2,4-Pyrimidinediamine, 5-(3,4-dichlorophenyl)-6-methyl-
- Inhibitor,histamine,HMT,Antifolate,barrier,Metoprine,Histone Methyltransferase,antitumor,N-methyltransferase,diaminopyrimidine,inhibit,BW 197U,blood-brain
- U-197
- NSC-19494
- DDMP
- BW-50-197
- 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE
- methodichlorophen
- Metoprine
- SK 5265
- NSC 7364
- BW 197U
- 5-(3,4-Dichlorophenyl)-6-Methyl-2,4-pyriMidinediaMine
- 5-(3,4-dichlorophenyl)-6-MethylpyriMidine-2,4-diaMine