SDZ-MKS 492
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- CAS号:
- 114606-56-3
- 英文名:
- SDZ MKS 492
- 英文别名:
- MKS 492;SDZ MKS 492;SDZ MKS 492,SDZMKS 492;1H-Purine-2,6-dione, 8-[[(1R)-1-(3,4-dimethoxyphenyl)-2-hydroxyethyl]amino]-3,7-dihydro-7-(2-methoxyethyl)-1,3-dimethyl-
- 中文名:
- SDZ-MKS 492
- 中文别名:
- 化合物 T12873
- CBNumber:
- CB31396204
- 分子式:
- C20H27N5O6
- 分子量:
- 433.46
- MOL File:
- 114606-56-3.mol
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SDZ-MKS 492化学性质
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沸点:
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648.7±65.0 °C(Predicted)
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密度:
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1.36±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 250 mg/mL (576.75 mM; Need ultrasonic)
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酸度系数(pKa):
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14.25±0.10(Predicted)
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SDZ-MKS 492性质、用途与生产工艺
SDZ-MKS 492 (MKS 492) 一种选择性的环状 GMP 抑制的磷酸二酯酶 (III 型 PDE) 抑制剂。SDZ-MKS 492 抑制豚鼠和大鼠中抗原或血小板活化因子 (PAF) 诱导的支气管收缩和过敏反应。
type III phosphodiesterase
MKS 492 relaxes airway smooth muscle in vitro.
MKS-492 (3-10 mg/kg; i.v.) inhibits antigen-induced bronchoconstriction in guinea pigs.
MKS-492 (1-3 mg/kg; i.v.) inhibits PAF-induced bronchoconstriction and the increase in airway responsiveness to histamine in guinea pigs.
MKS-492 (30-100 mg/kg; i.p.) inhibits leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs.
MKS-492 (10-100 mg/kg; i.p.) inhibits passive cutaneous anaphylaxis and mediator-induced skin reactions in rats.
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Animal Model:
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Female Hartley guinea pigs (250-300 g) were passively sensitized with anti-BPO BGG guinea pig serum
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Dosage:
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3, 10 mg/kg
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Administration:
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I.v. 5 min before antigen challenge
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Result:
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Inhibited antigen-induced bron choconstriction in a dose-related manner.
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SDZ-MKS 492
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-100164 | SDZ-MKS 492 | | 1 mg | 1590元 |
| 2024/04/30 | HY-100164 | SDZ-MKS 492
SDZ-MKS 492 | 114606-56-3 | 5mg | 3500元 |
114606-56-3, SDZ-MKS 492 相关搜索:
- 化合物 T12873
- 114606-56-3
- SDZ MKS 492,SDZMKS 492
- 1H-Purine-2,6-dione, 8-[[(1R)-1-(3,4-dimethoxyphenyl)-2-hydroxyethyl]amino]-3,7-dihydro-7-(2-methoxyethyl)-1,3-dimethyl-
- MKS 492
- SDZ MKS 492