LY309887
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- CAS号:
- 127228-54-0
- 英文名:
- LY309887
- 英文别名:
- LY309887;LY309887,LY-309887;GQCXGHHHNACOGE-SKDRFNHKSA-N;L-Glutamic acid, N-[[5-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]-2-thienyl]carbonyl]-
- 中文名:
- LY309887
- 中文别名:
- 化合物 T15813
- CBNumber:
- CB32628067
- 分子式:
- C19H23N5O6S
- 分子量:
- 449.48
- MOL File:
- 127228-54-0.mol
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LY309887化学性质
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密度:
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1.68±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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3.50±0.10(Predicted)
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LY309887性质、用途与生产工艺
LY309887 是一种有效的二氢叶酸还原酶 (GARFT) 抑制剂，Ki 值为 6.5 nM，具有抗肿瘤活性。
Ki: 6.5 nM (GARFT), 1.78 nM (Folate receptor α), 18.2 nM (Folate receptor β)
LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a K
i
of 6.5 nM for human GARFT and also has high affinity at human folate receptor (FR)α and FRβ (K
i
, 1.78 nM and 18.2 nM, respectively). LY309887 is signigicantly cytotoxic against the human leukemia cell line CCRF-CEM with IC
50
of 9.9 nM.
LY309887 (3 mg/kg-100 mg/kg, i.p.) shows complete inhibition on the tumor growth in mice bearing C3H mammary cancer cells.
LY309887
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-10818 | LY309887 | | 1 mg | 1745元 |
| 2024/04/30 | HY-10818 | LY309887 | | 5 mg | 3840元 |
127228-54-0, LY309887 相关搜索:
- 化合物 T15813
- 127228-54-0
- L-Glutamic acid, N-[[5-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]-2-thienyl]carbonyl]-
- LY309887,LY-309887
- GQCXGHHHNACOGE-SKDRFNHKSA-N
- LY309887