2018282-44-3
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- CAS号:
- 2018282-44-3
- 英文名:
- BMT-145027
- 英文别名:
- BMT-145027;BMT145027;BMT 145027;Inhibitor,mGluR,inhibit,BMT-145027,BMT145027,BMT 145027,Metabotropic glutamate receptors;3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile;1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile, 3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl-
- 中文名:
- 2018282-44-3
- 中文别名:
- 化合物 T10573;化合物BMT-145027
- CBNumber:
- CB33153223
- 分子式:
- C23H14ClF3N4
- 分子量:
- 438.83
- MOL File:
- 2018282-44-3.mol
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2018282-44-3化学性质
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沸点:
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653.2±55.0 °C(Predicted)
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密度:
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1.51±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 2.4 mg/mL (5.47 mM)
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酸度系数(pKa):
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7.40±0.40(Predicted)
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2018282-44-3性质、用途与生产工艺
BMT-145027是 mGluR5 的正变构调节物且没有固有的激动剂活性，EC50值为47 nM。
BMT-145027 is a compound with high MsLM stability (85% remaining), acceptable potency (EC
50
=47 nM), and a modest decrease in planarity (Fsp3 = 0.17). Importantly, BMT-145027 lacks inherent mGluR5 agonist activity when tested at concentrations up to 16 μM.
Drug-treated and control mice are shown two identical objects. After a 24-h natural forgetting period, the mice are reintroduced to a familiar object while simultaneously presented with a novel object. Since mice spend more time exploring unfamiliar objects, improved memory is measured as time spent exploring the novel object. BMT-145027 leads to a significant increase in time spent with the novel object when dosed at 30 mg/kg, with an apparent trend in novel object preference at 10 mg/kg. Satellite animals indicates a total plasma concentration of 2800 nM at 30 mg/kg.
2018282-44-3
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100728 | 2018282-44-3
BMT-145027 | 2018282-44-3 | 5mg | 1900元 |
| 2024/04/30 | HY-100728 | 2018282-44-3
BMT-145027 | 2018282-44-3 | 10mg | 3200元 |
2018282-44-3, 2018282-44-3 相关搜索:
- 化合物BMT-145027
- 化合物 T10573
- 2018282-44-3
- Inhibitor,mGluR,inhibit,BMT-145027,BMT145027,BMT 145027,Metabotropic glutamate receptors
- BMT145027;BMT 145027
- 3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile
- 1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile, 3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl-
- BMT-145027