151165-96-7
|
|
|
- CAS号:
- 151165-96-7
- 英文名:
- S-8921
- 英文别名:
- S-8921;S 8921,S8921;methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylpentanoyl)-4-hydroxy-6,7,8-trimethoxynaphthalene-2-carboxylate;2-Naphthalenecarboxylic acid, 1-(3,4-dimethoxyphenyl)-3-(3-ethyl-1-oxopentyl)-4-hydroxy-6,7,8-trimethoxy-, methyl ester
- 中文名:
- 151165-96-7
- 中文别名:
- 化合物 T16818
- CBNumber:
- CB34796689
- 分子式:
- C30H36O9
- 分子量:
- 540.6
- MOL File:
- 151165-96-7.mol
|
|
|
151165-96-7化学性质
-
沸点:
-
664.9±55.0 °C(Predicted)
-
|
-
密度:
-
1.176±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
酸度系数(pKa):
-
7.00±0.50(Predicted)
-
|
151165-96-7性质、用途与生产工艺
S-8921 是一种回肠 Na+/胆汁酸协同转运蛋白 (IBAT) 的抑制剂。
S-8921 is an ileal Na
+
/bile acid cotransporter (IBAT) inhibitor. S-8921 inhibits the uptake velocity of 60 μM [
3
H] taurocholate dose-dependently in IBAT-COS cells, and the IC
50
value of S-8921 is 66±8 μM.
Seven-day treatment with S-8921 causes a dramatic decrease of serum cholesterol concentrations in hamsters. The hypocholesterolemic effects of S-8921 are dose-dependent, but S-8921 does not affect body weight. An increase of fecal bile acid excretion is observed especially at higher doses of S-8921. S-8921 treatment for 1 to 2 weeks causes a decrease in serum total cholesterol concentrations, with 0.01% S-8921 (4.0 to 4.6 mg/kg) being almost maximally effective.
151165-96-7
上下游产品信息
上游原料
下游产品
151165-96-7, 151165-96-7 相关搜索:
- 化合物 T16818
- 151165-96-7
- S 8921,S8921
- methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylpentanoyl)-4-hydroxy-6,7,8-trimethoxynaphthalene-2-carboxylate
- 2-Naphthalenecarboxylic acid, 1-(3,4-dimethoxyphenyl)-3-(3-ethyl-1-oxopentyl)-4-hydroxy-6,7,8-trimethoxy-, methyl ester
- S-8921