Norbinaltorphimine Dihydrochloride

生物活性靶点体外研究体内研究

CAS号:: 113158-34-2

英文名:: Norbinaltorphimine Dihydrochloride

英文别名:: (1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol

中文名:: Norbinaltorphimine Dihydrochloride

中文别名:: 化合物 T12241

CBNumber:: CB34806515

分子式:: C40H44ClN3O6

分子量:: 698.26

MOL File:: 113158-34-2.mol

化学性质安全信息用途供应商 16

Norbinaltorphimine Dihydrochloride化学性质

熔点:: >280 °C (decomp)

储存条件:: Store at RT

溶解度:: Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO

形态:: Powder

安全信息

Norbinaltorphimine Dihydrochloride性质、用途与生产工艺

生物活性

Norbinaltorphimine dihydrochloride是一种有效的和选择性的κ阿片受体 (κ opioid receptor) 拮抗剂。

Norbinaltorphimine reversibly antagonize the effects of κ agonists with pA2 values of 10.2-10.4. Norbinaltorphimine is much less potent as an antagonist at μ and δ receptors, pA2 values are 7.4-7.6 and 7.6-7.8, respectively.

体内研究

Norbinaltorphimine has weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that Norbinaltorphimine both attenuates and strengthens taste avoidance dependent on dose and trial. Norbinaltorphimine has limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, Norbinaltorphimine has no effect on THC-induced taste avoidance in adult rats as well. Norbinaltorphimine pretreatment significantly attenuates stress-induced reinstatement of nicotine-CPP, but has no effect on nicotine-primed reinstatement.

Norbinaltorphimine Dihydrochloride 上下游产品信息

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Norbinaltorphimine Dihydrochloride 生产厂家

全球有 16家供应商 Norbinaltorphimine Dihydrochloride国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
上海一飞生物科技有限公司	021-65675885 18964387627	info@efebio.com	中国	9709	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
BOC Sciences		info@bocsci.com	美国	0	65
ChemeGen 中国	18818260767	sales@chemegen.com	中国	11289	58
安耐吉化学&3A（安徽泽升科技有限公司）	021-58432009 400-005-6266	marketing1@energy-chemical.com	中国	44843	58
成都超九八生物科技有限公司	13348960310 13348960310	3003867561@qq.com	中国	9946	58
天津普西唐生物医药科技有限公司	010-60605840	psaitong@jm-bio.com	中国	29778	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24018	58
南通全益生物科技有限公司	0513-66337626 18051384581	sales@chemhifuture.com	中国	4191	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	中国	43348	58
ApexBio技术		sales@apexbt.com	美国	6254	58

113158-34-2, Norbinaltorphimine Dihydrochloride 相关搜索:

纳曲吲哚盐酸盐 SDM25Nhydrochloride

化合物 T12241
113158-34-2
(1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol