SNT-207858 free base
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- CAS号:
- 1104662-66-9
- 英文名:
- SNT-207858 free base
- 英文别名:
- SNT-207858 free base;SNT207858 free base,SNT 207858 free base;1-Pyrrolidinecarboxamide, N-[(1R)-1-[(2,4-dichlorophenyl)methyl]-2-oxo-2-[4-[3-[(2R)-2-(1-pyrrolidinyl)butoxy]-2-pyridinyl]-1-piperidinyl]ethyl]-
- 中文名:
- SNT-207858 free base
- 中文别名:
- 化合物 T12945
- CBNumber:
- CB35821344
- 分子式:
- C32H43Cl2N5O3
- 分子量:
- 616.62
- MOL File:
- 1104662-66-9.mol
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SNT-207858 free base化学性质
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沸点:
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813.0±65.0 °C(Predicted)
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密度:
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1.258±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 125 mg/mL (202.72 mM)
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酸度系数(pKa):
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12.71±0.20(Predicted)
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SNT-207858 free base性质、用途与生产工艺
SNT-207858 free base 是一种选择性，能透过血脑屏障的，有口服活性的黑皮质素 (melanocortin; MC-4) 受体拮抗剂，SNT-207858 free base 抑制与 MC-4 受体结合，IC50 为 22 nM。SNT-207858 抑制 MC-4 活性，IC50 为 11 nM。
SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5.
SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice.
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Animal Model:
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Mice with C26 adenocarcinoma-induced cachexia model
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Dosage:
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30 mg/kg
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Administration:
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Oral administration; once daily; 15 days
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Result:
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Significantly reduced the tumor induced weight loss.
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SNT-207858 free base
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-11030A | SNT-207858 free base | | 1 mg | 2045元 |
| 2024/04/30 | HY-11030A | SNT-207858 free base
SNT-207858 free base | 1104662-66-9 | 5mg | 4500元 |
SNT-207858 free base
生产厂家
1104662-66-9, SNT-207858 free base 相关搜索:
- C32H43Cl2N5O3
- 化合物 T12945
- 1104662-66-9
- SNT207858 free base,SNT 207858 free base
- 1-Pyrrolidinecarboxamide, N-[(1R)-1-[(2,4-dichlorophenyl)methyl]-2-oxo-2-[4-[3-[(2R)-2-(1-pyrrolidinyl)butoxy]-2-pyridinyl]-1-piperidinyl]ethyl]-
- SNT-207858 free base