PROTAC AR Degrader-4
|
|
|
- CAS号:
- 1351169-31-7
- 英文名:
- PROTAC AR Degrader-4
- 英文别名:
- PROTAC AR Degrader-4;Androstan-3-one, 17-[[(14S,17S,18R)-18-amino-17-hydroxy-14-(2-methylpropyl)-1,13,16-trioxo-19-phenyl-3,6,9-trioxa-12,15-diazanonadec-1-yl]oxy]-, (5α,17β)-
- 中文名:
- PROTAC AR Degrader-4
- 中文别名:
- CBNumber:
- CB38054802
- 分子式:
- C43H67N3O9
- 分子量:
- 770.01
- MOL File:
- 1351169-31-7.mol
|
|
|
PROTAC AR Degrader-4化学性质
-
沸点:
-
906.4±65.0 °C(Predicted)
-
|
-
密度:
-
1.19±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
酸度系数(pKa):
-
10.90±0.45(Predicted)
-
|
PROTAC AR Degrader-4性质、用途与生产工艺
PROTAC AR Degrader-4 包含 cIAP1 配体结合基团，linker 和雄激素受体 (AR) 配体结合基团。基于 cIAP1 的降解剂也被称为 SNIPER。
Specific and Nongenetic IAPs-dependent Protein Erasers (SNIPERs) are bifunctional compounds which are designed by conjugating an IAPs-recognition structure with a target protein-recognition structure.
Targeting proteins for degradation involves three steps.
1, its two recognition structures allow SNIPER to form a complex linking IAPs, which have E3 ligase activity, with the target protein.
2, the target protein is polyubiquitinated by IAPs.
3, the polyubiquitinated protein is degraded by proteasome.
PROTAC AR Degrader-4
上下游产品信息
上游原料
下游产品
PROTAC AR Degrader-4
生产厂家
1351169-31-7, PROTAC AR Degrader-4 相关搜索:
- 1351169-31-7
- Androstan-3-one, 17-[[(14S,17S,18R)-18-amino-17-hydroxy-14-(2-methylpropyl)-1,13,16-trioxo-19-phenyl-3,6,9-trioxa-12,15-diazanonadec-1-yl]oxy]-, (5α,17β)-
- PROTAC AR Degrader-4