NSC403140
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- CAS号:
- 466-75-1
- 英文名:
- NSC403140
- 英文别名:
- NSC403140;Natalensine;Hemanthamine;Haemanthamine;3-Epicrinamine
- 中文名:
- NSC403140
- 中文别名:
- 化合物 T11534
- CBNumber:
- CB41250334
- 分子式:
- C17H19NO4
- 分子量:
- 301.33706
- MOL File:
- 466-75-1.mol
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NSC403140化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 100 mg/mL (331.85 mM; Need ultrasonic)
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NSC403140性质、用途与生产工艺
Haemanthamine 是从 Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱,具有强大的抗癌活性。Haemanthamine 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine 具有促凋亡,抗氧化剂,抗病毒,抗疟疾和抗惊厥活性。
Haemanthamine (1-100 µM; 24-48 hours; A2780 cells) treatment shows a time- and dose-dependent decrease in cell viability.
Haemanthamine (10 µM; 24-72 hours; A2780 cells) treatment leads to a significant inhibition of A2780 cell proliferation.
Haemanthamine binds at the A-site cleft of the peptidyl transferase center on the large ribosomal subunit, creating unique molecular interactions with the 25S rRNA. Haemanthamine has a highly specific inhibitory effect on pre-rRNA processing, leading to the activation of a p53-dependent antitumoral surveillance pathway known as nucleolar stress.
Cell Viability Assay
Cell Line:
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A2780 ovarian cancer cells
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Concentration:
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1 µM, 10 µM, 50 µM, 100 µM
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Incubation Time:
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24 hours, 48 hours
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Result:
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Showed a time- and dose-dependent decrease in cell viability.
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Cell Proliferation Assay
Cell Line:
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A2780 ovarian cancer cells
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Concentration:
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10 µM
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Incubation Time:
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24 hours, 48 hours, 72 hours
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Result:
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Led to a significant inhibition of A2780 cell proliferation.
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A pharmacokinetic study of Haemanthamine in rats shows a rapid distribution phase of 30 min, a half-life of 70.4 min, and a major clearance through renal elimination. The high distribution volume of 13.7 L/kg suggests a high intracellular penetration, and its plasmatic concentration remains higher than 1 μM for at least 1 hr after a single 10-mg/kg administration.
NSC403140
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-114489A | NSC403140 Haemanthamine | 466-75-1 | 1 mg | 4100元 |
466-75-1, NSC403140 相关搜索:
- 化合物 T11534
- 466-75-1
- Natalensine
- Hemanthamine
- Haemanthamine
- 3-Epicrinamine
- NSC403140